Limited small cell lung cancer: Prognostic significance of a complete response to the induction phase of chemotherapy followed by thoracic irradiation Journal Article
| Authors: | Armstrong, J. G.; Rosenstein, M. M.; Scher, H. I.; Fass, D. E.; Zelefsky, M. J.; Kris, M. G. |
| Article Title: | Limited small cell lung cancer: Prognostic significance of a complete response to the induction phase of chemotherapy followed by thoracic irradiation |
| Abstract: | Limited-stage small cell lung cancer is frequently treated with induction combination chemotherapy (ICC), followed by consolidation with thoracic irradiation. It has been suggested that patients who do not have a complete response to ICC are unlikely to have control of occult distant metastasis and consequently have such a poor prognosis that thoracic irradiation is unlikely to be of benefit. To examine this hypothesis, 48 patients treated on prospective protocols who achieved a complete response to ICC or subsequently to thoracic irradiation were analyzed. Twenty-four patients had a complete response to ICC (CR-ICC), and 24 subsequently converted to complete-response status after thoracic irradiation (CR-TI). The two groups had similar prognostic factors and treatment. Comparing CR-ICC and CR-TI patients, survival was 40% versus 26% at 2 years and 35% versus 4% at 5 years, respectively (P < .05). Freedom from distant metastasis was 41% at 5 years for the CR-ICC patients and 8% for the CR-TI patients (P < .05). A modest number of CR-TI patients were long-term survivors, suggesting a value for thoracic irradiation as consolidation therapy. |
| Keywords: | adult; cancer chemotherapy; clinical article; aged; cisplatin; doxorubicin; treatment planning; conference paper; cancer radiotherapy; comparative study; combined modality therapy; etoposide; antineoplastic combined chemotherapy protocols; lung neoplasms; cyclophosphamide; vincristine; lung small cell cancer; radiotherapy, high-energy; intravenous drug administration; carcinoma, small cell; middle age; prognosis; human; male; female; priority journal; lung neoplasms, therapeutic radiology, 60.321; lung neoplasms, therapy, 60.321 |
| Journal Title: | Radiology |
| Volume: | 178 |
| Issue: | 3 |
| ISSN: | 0033-8419 |
| Publisher: | Radiological Society of North America, Inc. |
| Date Published: | 1991-03-01 |
| Start Page: | 875 |
| End Page: | 878 |
| Language: | English |
| DOI: | 10.1148/radiology.178.3.1847240 |
| PUBMED: | 1847240 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
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