Therapeutic cloning in individual parkinsonian mice Journal Article
| Authors: | Tabar, V.; Tomishima, M.; Panagiotakos, G.; Wakayama, S.; Menon, J.; Chan, B.; Mizutani, E.; Al Shamy, G.; Ohta, H.; Wakayama, T.; Studer, L. |
| Article Title: | Therapeutic cloning in individual parkinsonian mice |
| Abstract: | Cell transplantation with embryonic stem (ES) cell progeny requires immunological compatibility with host tissue. 'Therapeutic cloning' is a strategy to overcome this limitation by generating nuclear transfer (nt)ES cells that are genetically matched to an individual. Here we establish the feasibility of treating individual mice via therapeutic cloning. Derivation of 187 ntES cell lines from 24 parkinsonian mice, dopaminergic differentiation, and transplantation into individually matched host mice showed therapeutic efficacy and lack of immunological response. © 2008 Nature Publishing Group. |
| Keywords: | controlled study; treatment outcome; transplantation, homologous; nonhuman; animal cell; mouse; animals; mice; mus; embryo; embryonic stem cell; cell line; animal experiment; animal model; stem cell transplantation; neurons; mice, inbred balb c; mice, transgenic; molecular cloning; immune response; embryonic stem cells; nerve cell differentiation; transplantation, autologous; dopamine; dopaminergic nerve cell; host; behavior, animal; mice, congenic; parkinsonism; cell nucleus transplantation; parkinsonian disorders; cloning, organism; nuclear transfer techniques; parkinsonia |
| Journal Title: | Nature Medicine |
| Volume: | 14 |
| Issue: | 4 |
| ISSN: | 1078-8956 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2008-04-01 |
| Start Page: | 379 |
| End Page: | 381 |
| Language: | English |
| DOI: | 10.1038/nm1732 |
| PUBMED: | 18376409 |
| PROVIDER: | scopus |
| PMCID: | PMC2786166 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 43" - "Export Date: 17 November 2011" - "CODEN: NAMEF" - "Source: Scopus" |
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