Phase II trial of esorubicin (4′ deoxydoxorubicin, DxDx) in patients with small cell lung cancer Journal Article
| Authors: | Rigas, J. R.; Kris, M. G.; Gralla, R. J.; Heelan, R. T.; Marks, L. D. |
| Article Title: | Phase II trial of esorubicin (4′ deoxydoxorubicin, DxDx) in patients with small cell lung cancer |
| Abstract: | Esorubicin (4′-deoxydoxorubicin or DxDx) is an analog of doxorubicin with preclinical antitumor activity and no significant cardiotoxicity in model systems. Eleven patients with small cell lung cancer who had previously received chemotherapy were given esorubicin (25 mg/m2 intravenously) every 3 weeks. No major objective responses were observed (95% confidence limits: 0-25%). Nine of the 11 patients had grade 2 or greater toxicity, with 55% of the patients experiencing grade 3 or greater toxicity [myelosuppression (4/11), anemia (2/11) or elevated liver enzymes (3/11)]. Nausea, vomiting, alopecia and intravenous site phlebitis were also seen. Three of the 11 patients received 3 or more course of esorubicin without evidence of significant cardiotoxicity. At this dose and shedule, no significant antitumor response were seen in this population of patients. Esorubicin, with this low response rate and significant toxicity, appears to be of limited utility in this disease. © 1991 Kluwer Academic Publishers. |
| Keywords: | adult; clinical article; aged; doxorubicin; phase 2 clinical trial; anemia; bone marrow suppression; lung neoplasms; lung cancer; antibiotics, antineoplastic; alopecia; intravenous drug administration; small cell carcinoma; small cell lung cancer; carcinoma, small cell; phase ii trial; middle age; drug evaluation; human; male; female; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; esorubicin; deoxydoxorubicin |
| Journal Title: | Investigational New Drugs |
| Volume: | 9 |
| Issue: | 2 |
| ISSN: | 0167-6997 |
| Publisher: | Springer |
| Date Published: | 1991-05-01 |
| Start Page: | 187 |
| End Page: | 190 |
| Language: | English |
| DOI: | 10.1007/bf00175087 |
| PUBMED: | 1651908 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 27 September 2019 -- Source: Scopus |
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