A remote control process for the routine synthesis of branched chain [1-(11)C]α amino acids Journal Article
| Authors: | Fissekis, J. D.; Nielsen, C. M.; Tirelli, S.; Knott, A. F.; Dahl, J. R. |
| Article Title: | A remote control process for the routine synthesis of branched chain [1-(11)C]α amino acids |
| Abstract: | We describe the implementation of a modified Bucherer-Strecker synthesis for the facile production of several natural branched-chain, [11C]carboxy-labelled amino acids and of a carbocyclic analogue. The amino acids obtained by this process include the following: dl-Val, dl-Leu, dl-Ileu and α-amino-isobutyric and 1-amino-cyclopentane-1-carboxylic acids. A remote control apparatus specifically constructed for the routine, safe application of this process is also described. This apparatus allows the sequential batch-production of two amino acids, either the same of different, in average radiochemical yields between 1.48 and 2.59 GBq (40 and 70 mCi) and with average specific activities of 92.5 GBq (2.5 Ci)/mmol. © 1991. |
| Keywords: | controlled study; isotope labeling; amino acids; synthesis; carbon 11; article; chemical operations - remote control; bucherer-strecker synthesis; radiochemical yields; alpha amino acid |
| Journal Title: | International Journal of Radiation Applications and Instrumentation. Part A: Applied Radiation and Isotopes |
| Volume: | 42 |
| Issue: | 12 |
| ISSN: | 0883-2889 |
| Publisher: | Elsevier, Inc. |
| Date Published: | 1991-01-01 |
| Start Page: | 1169 |
| End Page: | 1176 |
| Language: | English |
| DOI: | 10.1016/0883-2889(91)90192-4 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Author Robert J. Dahl's first name and middle initial are reversed on the original publication -- Source: Scopus |
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