Interferon-α therapy in patients with Kaposi's Sarcoma and the acquired immunodeficiency syndrome Journal Article
| Authors: | Paredes, J.; Krown, S. E. |
| Article Title: | Interferon-α therapy in patients with Kaposi's Sarcoma and the acquired immunodeficiency syndrome |
| Abstract: | High dose IFN-α is an effective treatment for a subset of patients with Kaposi's Sarcoma, that is, those who lack systemic symptoms (e.g. fever, weight loss), and co-existing HIV-associated conditions (e.g. opportunistic infections), and whose cell-mediated immunity system is only mildly or moderately impaired. There is little evidence that the addition of chemotherapeutic agents to IFN-α improves treatment outcome. Response rates in excess of 40% have been reported with the addition of AZT to IFN-α, and may prove active in patients with more severely impaired T-cell immunity. There is evidence that in responding patients, IFN-α also suppresses HIV replication, and in vitro studies indicate synergistic suppression of HIV by the IFN-α-AZT combination; evidence for in vitro synergy is being sought. © 1992. |
| Keywords: | conference paper; alpha interferon; t lymphocyte; cellular immunity; drug therapy, combination; human immunodeficiency virus; acquired immune deficiency syndrome; acquired immunodeficiency syndrome; kaposi sarcoma; sarcoma, kaposi; interferon-alpha; zidovudine; recombinant alpha2a interferon; lymphocyte subpopulation; human; priority journal |
| Journal Title: | International Journal of Immunopharmacology |
| Volume: | 13 |
| Issue: | Suppl. 1 |
| ISSN: | 0192-0561 |
| Publisher: | Elsevier Ltd |
| Date Published: | 1991-01-01 |
| Start Page: | 77 |
| End Page: | 81 |
| Language: | English |
| DOI: | 10.1016/0192-0561(91)90128-t |
| PUBMED: | 1823908 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
