Stage IIB osteogenic sarcoma Journal Article
| Authors: | Glasser, D. B.; Lane, J. M. |
| Article Title: | Stage IIB osteogenic sarcoma |
| Abstract: | Two hundred seventy-one consecutive patients treated from 1976 through 1986 were reviewed to estimate long-term survival. Disease-free survival for the entire cohort was 77% at five years and 74% at ten years. Humeral lesions had the best probability of survival (84% at ten years), followed by tibial lesions (81%) and femoral lesions (67%). Histologic response to preoperative chemotherapy was the strongest predictor of outcome. Those with little response had a survival estimate of 54% at ten years as compared to 68% for partial responders and approximately 90% for complete responders. Local recurrence was seen in 6.6% and was associated with an adverse effect on survival. Only two of the 18 patients with local recurrence have been rendered long-term disease-free survivors. |
| Keywords: | osteosarcoma; adolescent; adult; cancer chemotherapy; cancer survival; child; bone neoplasms; child, preschool; survival analysis; humerus; limb salvage; survival rate; major clinical study; cancer recurrence; doxorubicin; cancer adjuvant therapy; postoperative care; preoperative care; combined modality therapy; methotrexate; cancer staging; neoplasm staging; cohort studies; neoplasm recurrence, local; antineoplastic combined chemotherapy protocols; cyclophosphamide; predictive value of tests; clinical protocols; dactinomycin; amputation; bleomycin; new york city; femur; tibia; osteotomy; limb amputation; middle age; human; male; female; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s. |
| Journal Title: | Clinical Orthopaedics and Related Research |
| Volume: | 270 |
| ISSN: | 0009-921X |
| Publisher: | Springer |
| Date Published: | 1991-09-01 |
| Start Page: | 29 |
| End Page: | 39 |
| Language: | English |
| PUBMED: | 1715819 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 27 September 2019 -- Source: Scopus |
