Oncogenic Signals as Treatment Targets in Classic Myeloproliferative Neoplasms Journal Article
| Authors: | Tefferi, A.; Levine, R. L.; Kantarjian, H. |
| Article Title: | Oncogenic Signals as Treatment Targets in Classic Myeloproliferative Neoplasms |
| Abstract: | Therapeutically validated oncoproteins in myeloproliferative neoplasms (MPNs) include BCR-ABL in chronic myelogenous leukemia (CML) and a spectrum of PDGFRA/B mutant proteins that are products of intra- (eg, FIP1L1-PDGFRA) or interchromosomal (eg, ETV6-PDGFRB) gene fusions. Other MPN-relevant putative oncogenes that are awaiting therapeutic validation, include JAK2 and MPL mutations in polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF); KITD816V and other KIT mutations in systemic mastocytosis, and FGFR1 rearrangements associated with the 8p11 leukemia/lymphoma syndrome. The current review focuses on mutant molecules of interest in classic MPNs (ie, CML, PV, ET, and PMF) in the context of their value as drug targets. © 2009 American Society for Blood and Marrow Transplantation. |
| Keywords: | leukemia; myelofibrosis; gene mutation; exon; mutation; myeloproliferative disorder; janus kinase 2; thrombopoietin receptor; clinical trial; disease course; myeloid metaplasia; interferon; nonhuman; alpha interferon; cytarabine; imatinib; platelet derived growth factor alpha receptor; dasatinib; chronic myeloid leukemia; mutational analysis; oncogene; hematologic malignancy; polycythemia; gene rearrangement; guanosine; drug response; gene fusion; chromosome translocation; bcr abl protein; chromosome 8p; sequence homology; nilotinib; fibroblast growth factor receptor 1; thymidine; polycythemia vera; thrombocythemia; platelet derived growth factor beta receptor; transcription factor etv6; mastocytosis |
| Journal Title: | Biology of Blood and Marrow Transplantation |
| Volume: | 15 |
| Issue: | 1 SUPPL. |
| ISSN: | 1083-8791 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2009-01-01 |
| Start Page: | 114 |
| End Page: | 119 |
| Language: | English |
| DOI: | 10.1016/j.bbmt.2008.10.010 |
| PROVIDER: | scopus |
| PUBMED: | 19147089 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 2" - "Export Date: 30 November 2010" - "CODEN: BBMTF" - "Source: Scopus" |
