Genetic influences in opioid analgesic sensitivity in mice Journal Article
| Authors: | Pick, C. G.; Cheng, J.; Paul, D.; Pasternak, G. W. |
| Article Title: | Genetic influences in opioid analgesic sensitivity in mice |
| Abstract: | Studies of various strains of mice revealed marked differences in their analgesic sensitivity towards morphine (μ), U50,488H (κ1) and naloxone benzoylhydrazone (NalBzoH; κ3). Sensitivity to μ and κ analgesia varied independently of the other. Analgesic sensitivity to morphine remained relatively consistent among 3 different nociceptive assays for each strain. However, the sensitivity of an individual strain to NalBzoH remained highly dependent upon the assay used. CD-1 mice were sensitive to NalBzoH in all 3 assays, but in BALB/c mice NalBzoH produced analgesia only in the hot plate and cold water tail-flick assays. In Swiss-Webster mice, NalBzoH was active in the radiant heat and cold water tail-flicks but inactive in the hot plate. Although the levels of μ, κ1 and κ3 binding in whole brain homogenates did vary somewhat, they did not correlate with analgesic sensitivity. These results suggests that the genetic controls over μ and κ analgesia operate independently and further illustrate the many difficulties in evaluating potential analgesics. © 1991. |
| Keywords: | controlled study; nonhuman; comparative study; mouse; animal; mice; animal tissue; pain; animal experiment; mice, inbred strains; species specificity; morphine; analgesics; analgesia; mu opiate receptor; receptors, opioid, mu; mutant; naloxone; pyrrolidines; enkephalin, ala(2)-mephe(4)-gly(5)-; 3,4 dichloro n methyl n [2 (1 pyrrolidinyl)cyclohexyl]benzeneacetamide methanesulfonate; kappa opiate receptor; receptors, opioid; μ receptor; male; priority journal; article; receptors, opioid, kappa; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; enkephalins; 3,4-dichloro-n-methyl-n-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-isomer; κ receptor |
| Journal Title: | Brain Research |
| Volume: | 566 |
| Issue: | 1-2 |
| ISSN: | 0006-8993 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 1991-12-06 |
| Start Page: | 295 |
| End Page: | 298 |
| Language: | English |
| DOI: | 10.1016/0006-8993(91)91712-a |
| PUBMED: | 1667610 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work