Microwave-assisted one step synthesis of 8-arylmethyl-9H-purin-6-amines Journal Article
| Authors: | Tao, H.; Kang, Y.; Taldone, T.; Chiosis, G. |
| Article Title: | Microwave-assisted one step synthesis of 8-arylmethyl-9H-purin-6-amines |
| Abstract: | Molecular chaperone heat shock protein 90 (Hsp90) is an important target in cancer and neurodegenerative diseases, and has rapidly become the focus of several drug discovery efforts. Among small molecule Hsp90 inhibitors with clinical applicability are derivatives of 8-arylmethyl-9H-purin-6-amine class. Here we report the use of microwave-assisted chemistry for the successful one-pot delivery of 8-arylmethyl-9H-purin-6-amines. We discuss the applicability as well as the limitations of this method towards the creation of a large chemical diversity in the 8-arylmethyl-9H-purin-6-amine series. © 2008 Elsevier Ltd. All rights reserved. |
| Keywords: | drug targeting; drug structure; drug discovery; drug synthesis; amines; heat shock protein 90 inhibitor; heat shock protein 90; purines; purine derivative; chemical reaction; one pot synthesis; hsp90; microwave-assisted organic synthesis; neurodegenerative diseases; microwave radiation; microwaves |
| Journal Title: | Bioorganic & Medicinal Chemistry Letters |
| Volume: | 19 |
| Issue: | 2 |
| ISSN: | 0960-894X |
| Publisher: | Pergamon-Elsevier Science Ltd |
| Date Published: | 2009-01-15 |
| Start Page: | 415 |
| End Page: | 417 |
| Language: | English |
| DOI: | 10.1016/j.bmcl.2008.11.057 |
| PUBMED: | 19058963 |
| PROVIDER: | scopus |
| PMCID: | PMC2732337 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 30 November 2010" - "CODEN: BMCLE" - "Source: Scopus" |
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