Tissue-based research in kidney cancer: current challenges and future directions Journal Article


Authors: Signoretti, S.; Bratslavsky, G.; Waldman, F. M.; Reuter, V. E.; Haaga, J.; Merino, M.; Thomas, G. V.; Pins, M. R.; Libermann, T.; Gillespie, J.; Tomaszewski, J. E.; Compton, C. C.; Hruszkewycz, A.; Linehan, W. M.; Atkins, M. B.
Article Title: Tissue-based research in kidney cancer: current challenges and future directions
Abstract: The past several years have seen unprecedented advances in the application of various therapeutic strategies for the treatment of patients with renal cancer. The availability of active immunotherapy, antiangiogenic therapy, and targeted therapy for this disease has brought front and center issues related to choosing the appropriate treatment for particular patient populations. It is increasingly evident that the most promising treatment selection strategies will incorporate identifying specific features of the tumor itself. To facilitate this move toward personalized medicine, it is critically important to establish some standard principles for renal cancer tissue collection, preparation, and analysis for translational research studies. In this article, we identify and discuss some critical issues related to tissue-based kidney cancer research. We focus on five major areas as follows: (a) surgical and image-guided techniques for tissue collection; (b) quality control of specimen collection, processing, storage, and review; (c) issues related to analysis of paraffin embedded tissues; (d) genomic studies; and (e) assessment of reproducibility of assays across institutions. In addition, some practical implementation strategies are proposed. Although many of the topics discussed are specific for renal cancer, several are also relevant to tissue based biomarker investigations in a broad array of malignancies. © 2008 American Association for Cancer Research.
Keywords: genetics; review; research design; methodology; reproducibility; biological marker; quality control; computer assisted tomography; biological model; models, biological; tumor markers, biological; analytic method; tumor biopsy; drug screening; pathology; drug evaluation, preclinical; transplantation; algorithms; tumor marker; cancer research; kidney carcinoma; kidney neoplasms; molecular mechanics; kidney tumor; carcinoma, renal cell; algorithm; evaluation; genomics; imaging; tissue and organ harvesting; tissue microarray; kidney cancer; tissue preparation; kidney parenchyma; tissue preservation; paraffin; surgery, computer-assisted; health care facility; paraffin embedding; tissue banks; computer assisted surgery
Journal Title: Clinical Cancer Research
Volume: 14
Issue: 12
ISSN: 1078-0432
Publisher: American Association for Cancer Research  
Date Published: 2008-06-15
Start Page: 3699
End Page: 3705
Language: English
DOI: 10.1158/1078-0432.ccr-07-4733
PUBMED: 18559586
PROVIDER: scopus
PMCID: PMC2586673
DOI/URL:
Notes: --- - "Cited By (since 1996): 9" - "Export Date: 17 November 2011" - "CODEN: CCREF" - "Source: Scopus"
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  1. Victor Reuter
    898 Reuter