Is possible to rule out clinically significant prostate cancer using PI-RADS v2 for the assessment of prostate MRI? Journal Article
| Authors: | Cavalcanti Viana, P. C.; Horvat, N.; dos Santos Júnior, V. R.; Lima, T. C.; Romão, D. S.; Cerri, L. M. O.; de Castro, M. G.; Vargas, H. A.; Miranda, J. A.; Leite, C. C.; Cerri, G. G. |
| Article Title: | Is possible to rule out clinically significant prostate cancer using PI-RADS v2 for the assessment of prostate MRI? |
| Abstract: | Objectives: To evaluate the diagnostic performance and interobserver agreement of PI-RADS v2. Materials and Methods: In this Institutional Review Board approved single-center retrospective study, 98 patients with clinically suspected PCa who underwent 3-T multiparametric MRI followed by MRI/TRUS fusion-guided prostate biopsy were included from June 2013 to February 2015. Two radiologists (R1 and R2) with 8 and 1 years of experience in abdominal radiology reviewed the MRI scans and assigned PI-RADS v2 scores in all prostate zones. PI-RADS v2 were compared to MRI/TRUS fusion-guided biopsy results, which were classified as negative, PCa, and significant PCa (sPCa). Results: Sensitivity, specificity, NPV, PPV and accuracy for PCa was 85.7% (same for all metrics) for R1 and 81.6%, 79.6%, 81.2%, 80.0% and 80.6% for R2. For detecting sPCa, the corresponding values were 95.3%, 85.4%, 95.9%, 83.7% and 89.8% for R1 and 93.0%, 81.8%, 93.7%, 86.7% and 86.7% for R2. There was substantial interobserver agreement in assigning PI-RADS v2 score as negative (1, 2, 3) or positive (4, 5) (Kappa=0.78). On multivariate analysis, PI-RADS v2 (p < 0.001) was the only independent predictor of sPCa compared with age, abnormal DRE, prostate volume, PSA and PSA density. Conclusions: Our study population demonstrated that PI-RADS v2 had high diagnostic accuracy, substantial interobserver agreement, and it was the only independent predictor of sPCa. © 2019, Brazilian Society of Urology. |
| Keywords: | aged; middle aged; retrospective studies; nuclear magnetic resonance imaging; magnetic resonance imaging; cancer grading; sensitivity and specificity; neoplasms; reproducibility; prostate specific antigen; reproducibility of results; observer variation; logistic models; risk factors; pathology; diagnostic imaging; retrospective study; risk factor; risk assessment; prostate-specific antigen; prostatic neoplasms; blood; prostate; prostate tumor; reference values; brazil; statistical model; statistics, nonparametric; reference value; nonparametric test; procedures; neoplasm grading; image guided biopsy; image-guided biopsy; humans; human; male; evaluation study |
| Journal Title: | International Brazilian Journal of Urology |
| Volume: | 45 |
| Issue: | 4 |
| ISSN: | 1677-5538 |
| Publisher: | Sociedade Brasileira de Urologia |
| Date Published: | 2019-07-01 |
| Start Page: | 724 |
| End Page: | 731 |
| Language: | English |
| DOI: | 10.1590/s1677-5538.Ibju.2018.0382 |
| PUBMED: | 31136114 |
| PROVIDER: | scopus |
| PMCID: | PMC6837601 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 October 2019 -- Source: Scopus |
