A comparison of intramedullary and juxtacortical low-grade osteogenic sarcoma Journal Article
| Authors: | Schwab, J. H.; Antonescu, C. R.; Athanasian, E. A.; Boland, P. J.; Healey, J. H.; Morris, C. D. |
| Article Title: | A comparison of intramedullary and juxtacortical low-grade osteogenic sarcoma |
| Abstract: | While low-grade juxtacortical and low-grade intramedullary osteogenic sarcomas are histologically indistinguishable, they have been studied as separate entities. We retrospectively reviewed the clinical, radiographic, histologic features and treatment of 59 patients treated surgically to compare the rate of local recurrence, grade progression, and survival between low-grade intramedullary and low-grade juxtacortical osteogenic sarcoma. Forty-five (76%) patients were treated for low-grade juxtacortical osteogenic sarcoma and 14 (24%) were treated for low-grade intramedullary osteogenic sarcoma. Local recurrence rates of 7% were similar for both groups studied. The rate of distant metastases was also similar for both groups. . The rate of dedifferentiation for the entire group was 29%. Dedifferentiated lesions were treated with adjuvant chemotherapy in 16 of 17 cases. Recurrence preceded dedifferentiation in four cases. Five-year survival was over 90% in both groups. Low-grade intramedullary and low-grade juxtacortical osteogenic sarcoma were clinically indistinguishable with identical rates of local recurrence, distant metastases, dedifferentiation, and survival. Level of Evidence: Level III, therapeutic study. See the Guidelines for Authors for a complete description of levels of evidence. © 2008 The Association of Bone and Joint Surgeons. |
| Keywords: | osteosarcoma; adolescent; adult; cancer survival; child; controlled study; school child; treatment outcome; aged; bone neoplasms; disease-free survival; middle aged; bone tumor; survival rate; retrospective studies; clinical feature; histopathology; mortality; cancer localization; cancer recurrence; cisplatin; doxorubicin; bone metastasis; conference paper; adjuvant therapy; comparative study; disease free survival; methotrexate; drug megadose; antineoplastic agent; cancer grading; cohort studies; cohort analysis; retrospective study; ewing sarcoma; adjuvant chemotherapy; cancer classification; sarcoma, ewing's; bone radiography; x ray; osteosarcoma, juxtacortical |
| Journal Title: | Clinical Orthopaedics and Related Research |
| Volume: | 466 |
| Issue: | 6 |
| ISSN: | 0009-921X |
| Publisher: | Springer |
| Date Published: | 2008-06-01 |
| Start Page: | 1318 |
| End Page: | 1322 |
| Language: | English |
| DOI: | 10.1007/s11999-008-0251-2 |
| PUBMED: | 18425560 |
| PROVIDER: | scopus |
| PMCID: | PMC2384019 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 6" - "Export Date: 17 November 2011" - "CODEN: CORTB" - "Source: Scopus" |
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