PET imaging for response assessment in lymphoma: Potential and limitations Journal Article
| Authors: | Schoder, H.; Moskowitz, C. |
| Article Title: | PET imaging for response assessment in lymphoma: Potential and limitations |
| Abstract: | Fluorodeoxyglucose positron emission tomography (FDG-PET) is now considered the most accurate tool for the assessment of treatment response and prognosis in patients with Hodgkin lymphoma and aggressive non-Hodgkin lymphoma. This article discusses the potential and limitations of FDG-PET for response assessment in malignant lymphoma during chemotherapy (interim PET) and at the end of chemotherapy. Interim PET is used to predict the likelihood for a complete response at the end of such therapy. End-of-treatment PET aims to establish the completeness of response or the presence of residual viable tumor tissue. Until the results of ongoing clinical trials emerge over the next 5 years, interim PET should be considered investigational and should not be used for patient management outside of study protocols. © 2008 Elsevier Inc. All rights reserved. |
| Keywords: | cancer chemotherapy; cancer survival; treatment outcome; treatment response; prednisone; clinical trial; review; cancer recurrence; doxorubicin; cancer risk; gemcitabine; cancer radiotherapy; rituximab; cancer staging; drug megadose; positron emission tomography; antineoplastic agent; cancer diagnosis; sensitivity and specificity; radiopharmaceuticals; carboplatin; dacarbazine; multiple cycle treatment; bone marrow suppression; tumor volume; etoposide; mucosa inflammation; neuropathy; tomography, x-ray computed; combination chemotherapy; cyclophosphamide; vincristine; patient assessment; stem cell transplantation; chlormethine; ifosfamide; procarbazine; vinblastine; hodgkin disease; monoclonal antibody; false negative result; b cell lymphoma; nonhodgkin lymphoma; lymphoma; fluorodeoxyglucose f18; positron-emission tomography; response; bleomycin; large cell lymphoma; tracer; cancer classification; pet; false positive result; false positive reactions; lung fibrosis; false negative reactions; fluorodeoxyglucose; burkitt lymphoma; gallium 67; scintigraphy; cardiomyopathy; fdg; lymphoblastoma; pet-ct; fluorothymidine f 18; monoclonal antibody cd 20 y 90; tioxamast |
| Journal Title: | Radiologic Clinics of North America |
| Volume: | 46 |
| Issue: | 2 |
| ISSN: | 0033-8389 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2008-03-01 |
| Start Page: | 225 |
| End Page: | 241 |
| Language: | English |
| DOI: | 10.1016/j.rcl.2008.04.002 |
| PUBMED: | 18619378 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 19" - "Export Date: 17 November 2011" - "CODEN: RCNAA" - "Source: Scopus" |
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