Positive cooperativity in the functioning of molecular chaperone GroEL Journal Article
| Authors: | Bochkareva, E. S.; Lissin, N. M.; Flynn, G. C.; Rothman, J. E.; Girshovich, A. S. |
| Article Title: | Positive cooperativity in the functioning of molecular chaperone GroEL |
| Abstract: | In the presence of its partner, GroES, the tetradecameric molecular chaperone GroEL binds 14 ATP molecules, half of which are hydrolyzed in a cooperative manner. Moreover GroEL can bind, with a positive cooperativity, more than two molecules of nonfolded protein rhodanese. The role of the cooperative mechanism in the functioning of GroEL is discussed. |
| Keywords: | protein; atp hydrolysis; association; escherichia-coli; purification; carboxylase; denatured rhodanese |
| Journal Title: | Journal of Biological Chemistry |
| Volume: | 267 |
| Issue: | 10 |
| ISSN: | 0021-9258 |
| Publisher: | American Society for Biochemistry and Molecular Biology |
| Date Published: | 1992-04-05 |
| Start Page: | 6796 |
| End Page: | 6800 |
| Language: | English |
| ACCESSION: | WOS:A1992HM05300052 |
| PROVIDER: | wos |
| PUBMED: | 1348056 |
| Notes: | Article -- Source: Wos |
