Primary bony and cartilaginous sarcomas of chest wall: Results of therapy Journal Article
| Authors: | Burt, M.; Fulton, M.; Wessner-Dunlap, S.; Karpeh, M.; Huvos, A. G.; Bains, M. S.; Martini, N.; McCormack, P. M.; Rusch, V. W.; Ginsberg, R. J. |
| Article Title: | Primary bony and cartilaginous sarcomas of chest wall: Results of therapy |
| Abstract: | Primary bony and cartilaginous sarcomas of the chest wall are uncommon, and data concerning treatment and results are sparse. To assess the results of therapy, we reviewed our 40-year experience. Records of 38 patients with osteosarcoma and 88 with chondrosarcoma arising in chest wall admitted to Memorial Sloan-Kettering Cancer Center from 1949 to 1989 were reviewed. The 88 patients with condrosarcoma ranged in age from 5 to 86 years (median age, 49 years); the male/female ratio was 1.3:1. Presenting complaint was mass, pain, or both in 93%. Primary therapy was resection (n = 84), radiation therapy (n = 3), or chemotherapy (n = 1). Overall 5-year survival was 64%. Significant adverse prognostic factors included metastases at initial presentation (n = 9), metastases at any time during the course of disease (n = 23), age greater than 50 years (n = 42), incomplete or no resection (n = 13), and local recurrence (n = 24). Sex, grade, and tumor size were not prognostic factors. The 38 patients with osteosarcoma ranged in age from 11 to 78 years (median age, 42 years); the male/female ratio was 1.5:1. Presenting complaint was mass, pain, or both in 95%. Primary therapy included resection (n = 31; alone in 13, with radiation therapy in 3, with chemotherapy in 15), radiation therapy (n = 3), radiation therapy and chemotherapy (n = 2), chemotherapy (n = 1), or no treatment (n = 1). Overall 5-year survival was 15%. Significant adverse prognostic factors included presence of synchronous metastases (n = 13) and metastases at any time during the course of disease (n = 26). Age, sex, tumor size, local recurrence, and extent of resection were not prognostic factors. In conclusion, patients with chest wall osteosarcoma have a significantly decreased 5-year survival (15%) compared with those with chondrosarcoma (64%). Resection allows acceptable survival for patients with chondrosarcoma, but the role of adjuvant therapy should continue to be explored in patients with osteosarcoma of chest wall. |
| Keywords: | osteosarcoma; chemotherapy; tumors; experience; chondrosarcoma; management; adjuvant; preoperative chemotherapy; factors affecting survival |
| Journal Title: | Annals of Thoracic Surgery |
| Volume: | 54 |
| Issue: | 2 |
| ISSN: | 0003-4975 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 1992-08-01 |
| Start Page: | 226 |
| End Page: | 232 |
| Language: | English |
| ACCESSION: | WOS:A1992JF48600006 |
| DOI: | 10.1016/0003-4975(92)91374-i |
| PROVIDER: | wos |
| PUBMED: | 1637209 |
| Notes: | Source: Wos |
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