A first-in-human, phase Ib combination study to assess safety, pharmacokinetics (PK), and pharmacodynamics (PD) of a hedgehog inhibitor, GDC-0449, with a Notch inhibitor, RO4929097, in patients with advanced sarcoma Meeting Abstract


Authors: Gounder, M. M.; Dickson, M. A.; Wu, N.; Ivy, S. P.; Carvajal, R. D.; D'Angelo, S. P.; Keohan, M. L.; Qin, L. X.; Erinjeri, J. P.; Takebe, N.; Tanner, L.; Morales, R.; Condy, M. M.; Ustoyev, Y.; Maki, R. G.; Tap, W. D.; Schwartz, G. K.
Abstract Title: A first-in-human, phase Ib combination study to assess safety, pharmacokinetics (PK), and pharmacodynamics (PD) of a hedgehog inhibitor, GDC-0449, with a Notch inhibitor, RO4929097, in patients with advanced sarcoma
Meeting Title: 48th Annual Meeting of the American Society of Clinical Oncology (ASCO)
Journal Title: Journal of Clinical Oncology
Volume: 30
Issue: 15 Suppl.
Meeting Dates: 2012 Jun 1-5
Meeting Location: Chicago, IL
ISSN: 0732-183X
Publisher: American Society of Clinical Oncology  
Date Published: 2012-05-20
Language: English
ACCESSION: WOS:000318009800594
PROVIDER: wos
DOI: 10.1200/jco.2012.30.15_suppl.10004
Notes: Meeting Abstract: 10004 -- Source: Wos
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MSK Authors
  1. Gary Schwartz
    385 Schwartz
  2. Richard D Carvajal
    148 Carvajal
  3. Robert Maki
    241 Maki
  4. Li-Xuan Qin
    194 Qin
  5. Mary Louise Keohan
    126 Keohan
  6. Mrinal M Gounder
    230 Gounder
  7. Sandra Pierina D'Angelo
    255 D'Angelo
  8. Joseph Patrick Erinjeri
    204 Erinjeri
  9. Nian Wu
    32 Wu
  10. Mark Andrew Dickson
    172 Dickson
  11. Mercedes M Condy
    19 Condy
  12. William Douglas Tap
    378 Tap
  13. Lanier R Tanner
    4 Tanner