The ups and downs of Src regulation: Tumor suppression by Cbp Journal Article
| Author: | Resh, M. D. |
| Article Title: | The ups and downs of Src regulation: Tumor suppression by Cbp |
| Abstract: | Tight control of the tyrosine kinase activity of c-Src is critical for regulating its oncogenic potential. In a recent issue of Molecular Cell, Oneyama et al. (2008a) report that the membrane-bound adaptor protein Cbp (also known as PAG) can suppress c-Src-mediated cell transformation and tumorigenesis by binding and sequestering c-Src within lipid rafts. Cbp is also a raft-associated binding partner for Csk, a negative regulator of c-Src. However, the authors show that Cbp-mediated Src suppression is Csk independent. These findings suggest that Cbp is a tumor suppressor whose expression is downregulated during Src-driven cancer progression. © 2008 Elsevier Inc. All rights reserved. |
| Keywords: | signal transduction; cell proliferation; animals; mice; mice, knockout; gene expression; membrane proteins; protein tyrosine kinase; carcinogenesis; cell transformation, neoplastic; cancer inhibition; gene expression regulation, neoplastic; cell transformation; tumor suppressor proteins; protein transport; fibroblasts; phosphoproteins; short survey; protein-tyrosine kinases; tumor suppressor protein; src-family kinases; adaptor protein; lipid raft; membrane microdomains; oncogene src; protein cbp |
| Journal Title: | Cancer Cell |
| Volume: | 13 |
| Issue: | 6 |
| ISSN: | 1535-6108 |
| Publisher: | Cell Press |
| Date Published: | 2008-06-10 |
| Start Page: | 469 |
| End Page: | 471 |
| Language: | English |
| DOI: | 10.1016/j.ccr.2008.05.011 |
| PUBMED: | 18538730 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 5" - "Export Date: 17 November 2011" - "CODEN: CCAEC" - "Source: Scopus" |
