The nutritional prevention of cancer: 400 Mcg per day selenium treatment Journal Article
| Authors: | Reid, M. E.; Duffield-Lillico, A. J.; Slate, E.; Natarajan, N.; Turnbull, B.; Jacobs, E.; Combs, G. F.; Alberts, D. S.; Clark, L. C.; Marshall, J. R. |
| Article Title: | The nutritional prevention of cancer: 400 Mcg per day selenium treatment |
| Abstract: | Nonexperimental studies suggest that individuals with higher selenium (Se) status are at decreased risk of cancer. The Nutritional Prevention of Cancer (NPC) study randomized 1,312 high-risk dermatology patients to 200-mcg/day of Se in selenized yeast or a matched placebo; selenium supplementation decreased the risk of lung, colon, prostate, and total cancers but increased the risk of nonmelanoma skin cancer. In this article, we report on a small substudy in Macon, GA, which began in 1989 and randomized 424 patients to 400-mcg/day of Se or to matched placebo. The subjects from both arms had similar baseline Se levels to those treated by 200 mcg, and those treated with 400-mcg attained plasma Se levels much higher than subjects treated with 200 mcg. The 200-mcg/day Se treatment decreased total cancer incidence by a statistically significant 25%; however, 400-mcg/day of Se had no effect on total cancer incidence. Copyright © 2008, Taylor & Francis Group, LLC. |
| Keywords: | controlled study; major clinical study; placebo; drug dose comparison; cancer patient; follow-up studies; cancer incidence; nutritional status; cancer prevention; skin neoplasms; incidence; skin cancer; risk factors; dose-response relationship, drug; diet supplementation; statistical significance; anticarcinogenic agents; patient compliance; dietary supplements; selenium; double-blind method; blood level; nutrition |
| Journal Title: | Nutrition and Cancer |
| Volume: | 60 |
| Issue: | 2 |
| ISSN: | 0163-5581 |
| Publisher: | Routledge |
| Date Published: | 2008-03-01 |
| Start Page: | 155 |
| End Page: | 163 |
| Language: | English |
| DOI: | 10.1080/01635580701684856 |
| PUBMED: | 18444146 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 24" - "Export Date: 17 November 2011" - "CODEN: NUCAD" - "Source: Scopus" |
