Challenges to the translation of genomic information into clinical practice and health policy: Utilization, preferences and economic value Journal Article
| Authors: | Phillips, K. A.; Liang, S. Y.; Van Bebber, S.; Afable-Munsuz, A.; Knight, S. J.; Kuppermann, M.; Ladabaum, U.; Walsh, J.; Elkin, E.; Haas, J.; Hassett, M.; Kulin, N.; Marshall, D.; Ponce, N. |
| Article Title: | Challenges to the translation of genomic information into clinical practice and health policy: Utilization, preferences and economic value |
| Abstract: | It is important to understand how knowledge of genomics can be translated from research into clinical practice and health policies. This review examines existing evidence on three key factors in the adoption of personalized medicine: utilization, preferences, and economic value, using two cancer examples: HER2/neu antigen testing and trastuzumab (Herceptin) treatment and genetic testing for Lynch syndrome. Our findings highlight areas in which additional research is required to build an evidence base addressing utilization of, preferences for, and the potential costs and benefits of personalized medicine. Major challenges include a lack of linked data, the need for relevant research frameworks and methodologies, and the clinical complexities of genomic-based diagnostics and treatment. © The Thomson Corporation. |
| Keywords: | review; cytotoxic agent; cancer combination chemotherapy; clinical practice; neoplasms; breast cancer; epidermal growth factor receptor 2; cancer screening; health care policy; economics; health policy; cancer genetics; antigen detection; genomics; health services research; familial cancer; trastuzumab; medicine; dna determination; economic aspect; personalized medicine; utilization; drug indication; preferences; economics, medical |
| Journal Title: | Current Opinion in Molecular Therapeutics |
| Volume: | 10 |
| Issue: | 3 |
| ISSN: | 1464-8431 |
| Publisher: | Thomson Reuters |
| Date Published: | 2008-06-01 |
| Start Page: | 260 |
| End Page: | 266 |
| Language: | English |
| PUBMED: | 18535933 |
| PROVIDER: | scopus |
| PMCID: | PMC2910510 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 10" - "Export Date: 17 November 2011" - "CODEN: CUOTF" - "Source: Scopus" |
