Nonenhancing component of clear cell renal cell carcinoma on computed tomography correlates with tumor necrosis and stage and serves as a size-independent prognostic biomarker Journal Article

   

Authors:	Ahmed, F. S.; Akin, O.; Shaish, H.; Luk, L.; Guo, X.; Yang, H.; Zabor, E.; Ostrovnaya, I.; Hakimi, A. A.; Zhao, B.; Schwartz, L. H.
Article Title:	Nonenhancing component of clear cell renal cell carcinoma on computed tomography correlates with tumor necrosis and stage and serves as a size-independent prognostic biomarker
Abstract:	Objectives: This study aimed to quantify nonenhancing tumor (NT) component in clear cell renal cell carcinoma (ccRCC) and assess its association with histologically defined tumor necrosis, stage, and survival outcomes. Methods: Among 183 patients with ccRCC, multi-institutional changes in computed tomography attenuation of tumor voxels were used to quantify percent of NT. Associations of NT with histologic tumor necrosis and tumor stage/grade were tested using Wilcoxon signed rank test and with survival outcomes using Kaplan-Meier curves/Cox regression analysis. Results: Nonenhancing tumor was higher in ccRCC with tumor necrosis (11% vs 7%; P = 0.040) and higher pathological stage (P = 0.042 and P < 0.001, respectively). Patients with greater NT had higher incidence of cancer recurrence after resection (P < 0.001) and cancer-specific mortality (P < 0.001). Conclusion: Nonenhancing tumor on preoperative computed tomographic scans in patients with ccRCC correlates with tumor necrosis and stage and may serve as an independent imaging prognostic biomarker for cancer recurrence and cancer-specific survival. © 2019 Wolters Kluwer Health, Inc. All rights reserved.
Keywords:	adult; aged; aged, 80 and over; middle aged; retrospective studies; mortality; pathology; diagnostic imaging; retrospective study; necrosis; renal cell carcinoma; kidney neoplasms; kidney tumor; carcinoma, renal cell; ct; clear cell renal cell carcinoma; very elderly; humans; prognosis; human; male; female; nonenhancing component; quantitative image biomarker
Journal Title:	Journal of Computer Assisted Tomography
Volume:	43
Issue:	4
ISSN:	0363-8715
Publisher:	Lippincott Williams & Wilkins
Date Published:	2019-07-01
Start Page:	628
End Page:	633
Language:	English
DOI:	10.1097/rct.0000000000000877
PUBMED:	31162237
PROVIDER:	scopus
PMCID:	PMC6629492
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85069669451&doi=10.1097%2fRCT.0000000000000877&partnerID=40&md5=532a6408a989b1d490911658fdd8f4ab
Notes:	Article -- Export Date: 4 September 2019 -- Source: Scopus

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