The good, the bad, and the ugly: Hyperprogression in cancer patients following immune checkpoint therapy Review

   


Authors: Sabio, E.; Chan, T. A.
Review Title: The good, the bad, and the ugly: Hyperprogression in cancer patients following immune checkpoint therapy
Abstract: Immune checkpoint blockade therapy can elicit robust and durable responses in a variety of cancer types. While many patients do not respond, recent reports highlight a distinct group of patients whose tumors undergo rapid growth, leading to progressive disease and poor outcome. In this perspective, we synthesize and summarize some important issues surrounding hyperprogression, defining characteristics, prognostic implications, and controversies.
Keywords: mutation; t cells; antigen; immune checkpoint; cancer; hyperprogression
Journal Title: Genome Medicine
Volume: 11
ISSN: 1756-994X
Publisher: Biomed Central Ltd  
Date Published: 2019-07-24
Start Page: 43
Language: English
DOI: 10.1186/s13073-019-0661-7
PUBMED: 31340855
PROVIDER: scopus
PMCID: PMC6651948
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85070533837&doi=10.1186%2fs13073-019-0661-7&partnerID=40&md5=955843311a5302261bd2afba32a887d7
Notes: Article -- Source: Scopus
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
MSK Authors
  1. Timothy Chan
    317 Chan
  2. Erich Sabio
    9 Sabio
Related MSK Work