Thrombosis in the Philadelphia chromosome-negative myeloproliferative neoplasms Journal Article
| Authors: | Sankar, K.; Stein, B. L.; Rampal, R. K. |
| Article Title: | Thrombosis in the Philadelphia chromosome-negative myeloproliferative neoplasms |
| Abstract: | The myeloproliferative neoplasms (MPNs) are clonal stem cell-derived diseases. This chapter focuses on the subcategory of Philadelphia (Ph) chromosome-negative classical MPNs, polycythemia vera (PV), essential thrombocythemia (ET), primary myelofibrosis (PMF). These MPNs are associated with both microvascular and macrovascular thrombosis, which may occur in the venous and arterial circulation. Erythrocytosis, leukocytosis, and increased JAK2V617F allele burden are known to be risk factors. In this chapter, we review the thrombotic and hemostatic manifestations of the Philadelphia (Ph) chromosome-negative classical MPNs, including the clinical manifestations, the pathophysiology, as well as management. © Springer Nature Switzerland AG 2019. |
| Keywords: | essential thrombocythemia; myelofibrosis; gene mutation; hydroxyurea; disease association; prevalence; risk factor; acetylsalicylic acid; cardiovascular risk; vein thrombosis; thrombosis; pregnancy; cell count; high risk population; artery thrombosis; myeloproliferative neoplasm; polycythemia vera; thrombocythemia; antithrombocytic agent; pennsylvania; myeloproliferative neoplasms; anagrelide; phlebotomy; antivitamin k; jak2v617f; ruxolitinib; disease burden; human; priority journal; microvascular thrombosis; thrombocytopheresis; macrovascular thrombosis |
| Journal Title: | Cancer Treatment and Research |
| Volume: | 179 |
| ISSN: | 0927-3042 |
| Publisher: | Springer |
| Date Published: | 2019-01-01 |
| Start Page: | 159 |
| End Page: | 178 |
| Language: | English |
| DOI: | 10.1007/978-3-030-20315-3_11 |
| PROVIDER: | scopus |
| PUBMED: | 31317487 |
| DOI/URL: | |
| Notes: | Chapter 11 in "Thrombosis and Hemostasis in Cancer" (ISBN: 978-3-030-20314-6) -- Source: Scopus |
