Insights into pediatric rhabdomyosarcoma research: Challenges and goals Review
| Authors: | Yohe, M. E.; Heske, C. M.; Stewart, E.; Adamson, P. C.; Ahmed, N.; Antonescu, C. R.; Chen, E.; Collins, N.; Ehrlich, A.; Galindo, R. L.; Gryder, B. E.; Hahn, H.; Hammond, S.; Hatley, M. E.; Hawkins, D. S.; Hayes, M. N.; Hayes-Jordan, A.; Helman, L. J.; Hettmer, S.; Ignatius, M. S.; Keller, C.; Khan, J.; Kirsch, D. G.; Linardic, C. M.; Lupo, P. J.; Rota, R.; Shern, J. F.; Shipley, J.; Sindiri, S.; Tapscott, S. J.; Vakoc, C. R.; Wexler, L. H.; Langenau, D. M. |
| Review Title: | Insights into pediatric rhabdomyosarcoma research: Challenges and goals |
| Abstract: | Overall survival rates for pediatric patients with high-risk or relapsed rhabdomyosarcoma (RMS) have not improved significantly since the 1980s. Recent studies have identified a number of targetable vulnerabilities in RMS, but these discoveries have infrequently translated into clinical trials. We propose streamlining the process by which agents are selected for clinical evaluation in RMS. We believe that strong consideration should be given to the development of combination therapies that add biologically targeted agents to conventional cytotoxic drugs. One example of this type of combination is the addition of the WEE1 inhibitor AZD1775 to the conventional cytotoxic chemotherapeutics, vincristine and irinotecan. © 2019 Wiley Periodicals, Inc. |
| Keywords: | genomics; rhabdomyosarcoma; cancer biology; early-phase clinical trials |
| Journal Title: | Pediatric Blood and Cancer |
| Volume: | 66 |
| Issue: | 10 |
| ISSN: | 1545-5009 |
| Publisher: | Wiley Periodicals, Inc |
| Date Published: | 2019-10-01 |
| Start Page: | e27869 |
| Language: | English |
| DOI: | 10.1002/pbc.27869 |
| PUBMED: | 31222885 |
| PROVIDER: | scopus |
| PMCID: | PMC6707829 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 30 August 2019 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work