Socioenvironmental adversity and risk of prostate cancer in non-Hispanic black and white men Journal Article


Authors: Kantor, E. D.; Haneuse, S.; Valdimarsdóttir, U. A.; Williams, D. R.; Signorello, L. B.; Rider, J. R.
Article Title: Socioenvironmental adversity and risk of prostate cancer in non-Hispanic black and white men
Abstract: Non-Hispanic black (NHB) men experience higher risk of prostate cancer than other racial/ethnic groups, and it is possible that socioenvironmental (SE) adversity and resulting stress may contribute to this disparity. Data from the Southern Community Cohort Study were used to evaluate associations between SE adversity and perceived stress in relation to prostate cancer risk, overall and by race/ethnicity and grade. Between 2002 and 2009, 26,741 men completed a questionnaire, from which an 8-item SE adversity composite was created (covering socioeconomic status, residential environment, and social support/buffers). Two items from the Perceived Stress Scale were assessed. With follow-up through 2011, 527 prostate cancer cases were diagnosed. In multivariable models, each one-unit increase in the SE adversity composite was associated with increased prostate cancer risk among non-Hispanic white (NHW) men (HR 1.23; 95% CI 1.02–1.48) and reduced risk among NHB men (HR 0.89; 95% CI 0.82–0.95) (p interaction: 0.001). This pattern held for low grade, but not high grade, cancers although power was limited for the latter. Perceived stress variables were associated with increased risk of prostate cancer among NHW men, but not among NHB men. Results do not support the hypothesis that SE adversity my underlay the racial disparity in prostate cancer, over and above that of covariates, including healthcare utilization. © 2019, Springer Nature Switzerland AG.
Keywords: prostate cancer; african americans; minority health; psychological stress; life stress
Journal Title: Cancer Causes & Control
Volume: 30
Issue: 9
ISSN: 0957-5243
Publisher: Springer  
Date Published: 2019-09-01
Start Page: 997
End Page: 1007
Language: English
DOI: 10.1007/s10552-019-01196-w
PUBMED: 31264140
PROVIDER: scopus
PMCID: PMC6744283
DOI/URL:
Notes: Article -- Export Date: 30 August 2019 -- Source: Scopus
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  1. Elizabeth David Kantor
    14 Kantor