Applying a conceptual model for examining health-related quality of life in long-term breast cancer survivors: CALGB study 79804 Journal Article
| Authors: | Paskett, E. D.; Herndon, J. E. 2nd; Day, J. M.; Stark, N. N.; Winer, E. P.; Grubbs, S. S.; Pavy, M. D.; Shapiro, C. L.; List, M. A.; Hensley, M. L.; Naughton, M. A.; Kornblith, A. B.; Habin, K. R.; Fleming, G. F.; Bittoni, M. A.; Weeks, J. C.; Dowell, J. |
| Article Title: | Applying a conceptual model for examining health-related quality of life in long-term breast cancer survivors: CALGB study 79804 |
| Abstract: | Objectives: The Survivor's Health and Reaction study used a quality-of-life model adapted for cancer survivors by Dow and colleagues to identify factors related to global health-related quality of life (HRQL) and to document the prevalence of problems and health-oriented behaviors in a follow-up study of breast cancer patients who participated in CALGB 8541. Methods: A total of 245 survivors (78% of those invited) who were 9.4-16.5 years post-diagnosis completed surveys that inquired about current HRQL, economic, spiritual, physical and psychosocial concerns, and health-oriented behaviors (e.g. smoking, exercise, and supplement use). A regression model was developed to examine factors related to global HRQL across all domains. Results: The regression model revealed that decreased energy levels (odds ratio (OR) 1.05, 95% confidence interval (CI): 1.03, 1.07), having heart disease (OR = 5.01, 95% CI: 1.39, 18.1), having two or more co-morbidities (OR = 2.39, 95% CI: 1.10, 5.19), and lower social support (OR = 1.03, 95% CI: 1.02, 1.05) were associated with lower global HRQL. Factors related to psychological, spiritual, and economic domains were not predictive of global HRQL. Regarding lifestyle changes, some women reported engaging in health-oriented behaviors since their cancer diagnosis, such as improving eating habits (54%), increasing exercise (32%), and reducing/quitting smoking (20%). The most prevalent problems reported by women at follow-up were menopausal symptoms (64%), such as hot flashes and vaginal dryness, osteoporosis (25%), and lymphedema (23%). Conclusion: Suggestions are provided to target interventions, such as provider-based strategies, in order to improve HRQL in long-term breast cancer survivors. Copyright © 2008 John Wiley & Sons, Ltd. |
| Keywords: | adult; controlled study; aged; disease-free survival; middle aged; major clinical study; doxorubicin; fluorouracil; cancer combination chemotherapy; dose response; drug dose comparison; chemotherapy, adjuvant; combined modality therapy; drug megadose; follow up; follow-up studies; neoplasm staging; low drug dose; quality of life; breast cancer; mastectomy; heart disease; antineoplastic combined chemotherapy protocols; estrogen; vaginal dryness; exercise; health behavior; randomized controlled trials as topic; smoking cessation; smoking; bisphosphonic acid derivative; cyclophosphamide; breast neoplasms; oncology; prediction; cancer survivor; survivors; lymphedema; social support; comorbidity; tamoxifen; sick role; hot flush; lifestyle modification; conceptual framework; religion; spirituality; socioeconomic factors; economic aspect; social psychology; eating habit; life style; menopausal syndrome; raloxifene; health behaviors; breast cancer survivor; postmenopause osteoporosis; climacteric |
| Journal Title: | Psycho-Oncology |
| Volume: | 17 |
| Issue: | 11 |
| ISSN: | 1057-9249 |
| Publisher: | John Wiley & Sons |
| Date Published: | 2008-11-01 |
| Start Page: | 1108 |
| End Page: | 1120 |
| Language: | English |
| DOI: | 10.1002/pon.1329 |
| PUBMED: | 18314912 |
| PROVIDER: | scopus |
| PMCID: | PMC3930158 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 7" - "Export Date: 17 November 2011" - "CODEN: POJCE" - "Source: Scopus" |
