Oncocytic neoplasms of the thyroid gland Journal Article


Authors: Tallini, G.; Carcangiu, M. L.; Rosai, J.
Article Title: Oncocytic neoplasms of the thyroid gland
Abstract: Among well differentiated thyroid tumors, oncocytic neo plasms feature a distinctive set of clinical, morphologic and biologic characteristics, some of which have been a matter of controversy. The world literature on this subject has been reviewed to show that: 1) Morphology accurately predicts the behavior of Hurthie cell tumors assuming that the specimen has been adequately sampled; 2) Capsular and/or vascular invasion is the sine qua non condition for a diagnosis of malignancy; 3) “Indeterminate” or “pos sibly malignant” categories are useless because in the absence of invasion these neoplasms almost invariably behave in a benign fashion; 4) Among cases histologically classified as malignant, a clinically aggressive behavior is to be expected in a high percentage of cases; 5) Size alone cannot be used as a criterion of malignancy; 6) Less than total thyroidectomy provides an adequate treatment for histologically benign tumors; aggressive surgical proce dures (i.e. total thyroidectomy) do not diminish the inci dence of metastasis; 7) Analysis of DNA content may be helpful in defining subsets of patients with Hurthle cell carcinomas having a particulaly poor prognosis; 8) Mito‐chondrial and/or nuclear DNA abnormalities probably play an important role in the cellular alterations which charac terize the phenotype of oncocytes. Acta Pathol Jpn 42: 305–315, 1992. Copyright © 1992, Wiley Blackwell. All rights reserved
Keywords: human tissue; review; oncocytoma; adenoma; carcinoma; thyroid carcinoma; thyroid neoplasms; thyroid; mitochondrial dna; terminology; thyroid adenoma; human; history of medicine, 20th cent.; oncocytic carcinoma; history of medicine, 19th cent.; hurthle cell tumor; oncocyte; oncocytic adenoma; oncocytic neoplasm
Journal Title: Acta Pathologica Japonica
Volume: 42
Issue: 5
ISSN: 0001-6632
Publisher: Wiley-Blackwell  
Date Published: 1992-05-01
Start Page: 305
End Page: 315
Language: English
DOI: 10.1111/j.1440-1827.1992.tb02879.x
PUBMED: 1636432
PROVIDER: scopus
DOI/URL:
Notes: Review -- Export Date: 30 July 2019 -- Source: Scopus
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  1. Juan Rosai
    181 Rosai
  2. Giovanni Tallini
    10 Tallini