Taking the time to make important decisions: The checkpoint effector kinases Chk1 and Chk2 and the DNA damage response Journal Article
| Authors: | Stracker, T. H.; Usui, T.; Petrini, J. H. J. |
| Article Title: | Taking the time to make important decisions: The checkpoint effector kinases Chk1 and Chk2 and the DNA damage response |
| Abstract: | The cellular DNA damage response (DDR) is activated by many types of DNA lesions. Upon recognition of DNA damage by sensor proteins, an intricate signal transduction network is activated to coordinate diverse cellular outcomes that promote genome integrity. Key components of the DDR in mammalian cells are the checkpoint effector kinases Chk1 and Chk2 (referred to henceforth as the effector kinases; orthologous to spChk1 and spCds1 in the fission yeast S. pombe and scChk1 and scRad53 in the budding yeast S. cerevisiae). These evolutionarily conserved and structurally divergent kinases phosphorylate numerous substrates to regulate the DDR. This review will focus on recent advances in our understanding of the structure, regulation, and functions of the effector kinases in the DDR, as well as their potential roles in human disease. © 2009 Elsevier B.V. All rights reserved. |
| Keywords: | signal transduction; nonhuman; protein function; mammalia; dna damage; cell cycle; mre11; nbs1; rad50; dna repair; apoptosis; dna; enzyme phosphorylation; enzyme regulation; saccharomyces cerevisiae; transcription; checkpoint kinase 2; saccharomycetales; checkpoint kinase 1; enzyme structure; atr; genetic conservation; schizosaccharomycetaceae; checkpoint; schizosaccharomyces pombe; atm; chk1; chk2; rad53; rad9; recombination; tel1 |
| Journal Title: | DNA Repair |
| Volume: | 8 |
| Issue: | 9 |
| ISSN: | 1568-7864 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2009-09-02 |
| Start Page: | 1047 |
| End Page: | 1054 |
| Language: | English |
| DOI: | 10.1016/j.dnarep.2009.04.012 |
| PROVIDER: | scopus |
| PMCID: | PMC2725228 |
| PUBMED: | 19473886 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 7" - "Export Date: 30 November 2010" - "CODEN: DRNEA" - "Source: Scopus" |
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