Challenging patient populations in breast cancer: Taxane resistance and triple-negative receptor subtype Journal Article
| Authors: | Ohno, S.; Fornier, M. N. |
| Article Title: | Challenging patient populations in breast cancer: Taxane resistance and triple-negative receptor subtype |
| Abstract: | Over the last decade the introduction of the taxanes and several targeted therapies have led to an improvement in breast cancer morbidity and mortality. However, several groups of patients, including patients with taxane-resistant, multidrug resistant, and estrogen-negative, progesterone-negative, and HER2/neu receptor-negative tumors, have now emerged that present challenges to clinicians as they strive to improve the outcomes for patients with breast cancer. This review examines the state of knowledge at the time of writing regarding the mechanisms of taxane resistance and the natural history of triple-negative disease. Strategies for overcoming taxane resistance and the improving clinical outcomes for these groups of patient are discussed. © 2008 The Authors Journal compilation © 2008 Blackwell Publishing Asia Pty Ltd. |
| Keywords: | signal transduction; cancer survival; clinical trial; disease course; review; doxorubicin; fluorouracil; drug efficacy; monotherapy; nonhuman; capecitabine; paclitaxel; unindexed drug; multiple cycle treatment; breast cancer; mastectomy; combination chemotherapy; cyclophosphamide; antineoplastic activity; structure activity relation; cancer resistance; docetaxel; breast carcinoma; drug response; epirubicin; vinca alkaloid; drug blood level; taxane derivative; cancer classification; anthracycline derivative; estrogen receptor; natural product; hormone receptor; cyclosporin a; drug treatment failure; verapamil; management; drug protein binding; multidrug resistance; ixabepilone; sagopilone; 21 aminoepothilone b; 9,10 didehydroepothilone d; epothilone a; epothilone b; epothilone d; epothilone derivative; taxane resistance; glycoprotein p; epipodophyllotoxin derivative; triple-negative; antimitotic agent; biricodar; glycoprotein p inhibitor; tariquidar; valspodar |
| Journal Title: | Asia-Pacific Journal of Clinical Oncology |
| Volume: | 4 |
| Issue: | SUPPL. 3 |
| ISSN: | 1743-7555 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2008-01-01 |
| Start Page: | S40 |
| End Page: | S48 |
| Language: | English |
| DOI: | 10.1111/j.1743-7563.2008.00193.x |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 17 November 2011" - "Source: Scopus" |
