Consistent biopsy quality and Gleason grading within the Global Active Surveillance Global Action Plan 3 initiative: A prerequisite for future studies Journal Article

  

Authors:	van der Kwast, T. H.; Helleman, J.; Nieboer, D.; Bruinsma, S. M.; Roobol, M. J.; The Movember Foundations Global Action Plan Prostate Cancer Active Surveillance (GAP3) Consortium
Contributors:	Ehdaie, B.; Benfante, N.
Article Title:	Consistent biopsy quality and Gleason grading within the Global Active Surveillance Global Action Plan 3 initiative: A prerequisite for future studies
Abstract:	Within the Movember Foundation's Global Action Plan Prostate Cancer Active Surveillance (GAP3) initiative, 25 centers across the globe collaborate to standardize active surveillance (AS) protocols for men with low-risk prostate cancer (PCa). A centralized PCa AS database, comprising data of more than 15 000 patients worldwide, was created. Comparability of the histopathology between the different cohorts was assessed by a centralized pathology review of 445 biopsies from 15 GAP3 centers. Grade group 1 (Gleason score 6) in 85% and grade group >= 2 (Gleason score >= 7) in 15% showed 89% concordance at review with moderate agreement (kappa = 0.56). Average biopsy core length was similar among the analyzed cohorts. Recently established highly adverse pathologies, including cribriform and/or intraductal carcinoma, were observed in 3.6% of the reviewed biopsies. In conclusion, the centralized pathology review of 445 biopsies revealed comparable histopathology among the 15 GAP3 centers with a low frequency of high-risk features. This enables further data analyses-without correction-toward uniform global AS guidelines for men with low-risk PCa. Patient summary: Movember Foundation's Global Action Plan Prostate Cancer Active Surveillance (GAP3) initiative combines data from 15 000 men with low-risk prostate cancer (PCa) across the globe to standardize active surveillance protocols. Histopathology review confirmed that the histopathology was consistent with low-risk PCa in most men and comparable between different centers. Crown Copyright (C) 2018 Published by Elsevier B.V. on behalf of European Association of Urology. All rights reserved.
Keywords:	prostate cancer; active surveillance; carcinoma; prostate-cancer; length; gleason grading; gap3 consortium; pathology review; biopsy quality
Journal Title:	European Urology Oncology
Volume:	2
Issue:	3
ISSN:	2588-9311
Publisher:	Elsevier BV
Date Published:	2019-05-01
Start Page:	333
End Page:	336
Language:	English
ACCESSION:	WOS:000474612900016
DOI:	10.1016/j.euo.2018.08.017
PROVIDER:	wos
PUBMED:	31200849
Notes:	Article -- Source: Wos

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