An improved method for detecting and delineating genomic regions with altered gene expression in cancer Journal Article
| Authors: | Nilsson, B.; Johansson, M.; Heyden, A.; Nelander, S.; Fioretos, T. |
| Article Title: | An improved method for detecting and delineating genomic regions with altered gene expression in cancer |
| Abstract: | Genomic regions with altered gene expression are a characteristic feature of cancer cells. We present a novel method for identifying such regions in gene expression maps. This method is based on total variation minimization, a classical signal restoration technique. In systematic evaluations, we show that our method combines top-notch detection performance with an ability to delineate relevant regions without excessive over-segmentation, making it a significant advance over existing methods. Software (Rendersome) is provided. © 2008 Nilsson et al.; licensee BioMed Central Ltd. |
| Keywords: | controlled study; genetics; solid tumor; molecular genetics; methodology; neoplasm; neoplasms; biology; gene expression profiling; computational biology; genetic variability; acute lymphoblastic leukemia; simulation; gene expression regulation; gene mapping; genome analysis; gene expression regulation, neoplastic; statistical analysis; cancer cell; methods; computer program; software; chromosome analysis; technique; chromosome map; chromosome mapping |
| Journal Title: | Genome Biology |
| Volume: | 9 |
| Issue: | 1 |
| ISSN: | 1465-6906 |
| Publisher: | Biomed Central Ltd |
| Date Published: | 2008-01-21 |
| Start Page: | R13 |
| Language: | English |
| DOI: | 10.1186/gb-2008-9-1-r13 |
| PUBMED: | 18208590 |
| PROVIDER: | scopus |
| PMCID: | PMC2395254 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 7" - "Export Date: 17 November 2011" - "CODEN: GNBLF" - "Source: Scopus" |
