Development and validation of a staging system for gastric adenocarcinoma after neoadjuvant chemotherapy and gastrectomy with D2 lymphadenectomy Journal Article

   

Authors:	Lin, J. X.; Yoon, C.; Desiderio, J.; Yi, B. C.; Li, P.; Zheng, C. H.; Parisi, A.; Huang, C. M.; Strong, V. E.; Yoon, S. S.
Article Title:	Development and validation of a staging system for gastric adenocarcinoma after neoadjuvant chemotherapy and gastrectomy with D2 lymphadenectomy
Abstract:	Background: Neoadjuvant chemotherapy followed by gastrectomy with D2 lymphadenectomy is commonly used for patients with locally advanced gastric adenocarcinoma. The eighth AJCC ypTNM staging system was validated based on patients undergoing more limited lymphadenectomy (less than D2). The aim of this study was to develop a system for accurate staging of patients with locally advanced gastric adenocarcinoma who receive neoadjuvant chemotherapy followed by gastrectomy with D2 lymphadenectomy. Methods: A modified system of ypTNM was developed, based on overall survival (OS) of patients receiving neoadjuvant chemotherapy followed by gastrectomy with D2 lymphadenectomy at Memorial Sloan Kettering Cancer Center, and validated using data from an international cohort of patients who had similar treatment. Results: Of 325 patients in the derivation cohort, 33 (10·2 per cent) had ypT0 N0/+ tumours, which are not classifiable under the AJCC system. The 5-year OS rate for modified ypTNM stages I, II, IIIA and IIIB was 89, 71, 42·3 and 10 per cent respectively, compared with 82, 65·2 and 24·1 for AJCC stages I, II and III respectively. The concordance index (0·730 versus 0·709), estimated area under the curve (0·765 versus 0·740) and time-dependent receiver operating characteristic (ROC) curve throughout the observation period were all superior for modified ypTNM staging. For the validation cohort of 186 patients, the modified system was again better at separating patients into prognostic groups for OS. Conclusion: The modified ypTNM staging system improves the accuracy of OS prediction for patients treated with neoadjuvant chemotherapy followed by gastrectomy with D2 lymphadenectomy. © 2019 BJS Society Ltd. Published by John Wiley & Sons Ltd
Journal Title:	British Journal of Surgery
Volume:	106
Issue:	9
ISSN:	0007-1323
Publisher:	Oxford University Press
Date Published:	2019-08-01
Start Page:	1187
End Page:	1196
Language:	English
DOI:	10.1002/bjs.11181
PUBMED:	31197829
PROVIDER:	scopus
PMCID:	PMC8194033
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85067390066&doi=10.1002%2fbjs.11181&partnerID=40&md5=52043667d02c9c22405ab9c954348425
Notes:	Article -- Source: Scopus

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