Neutrophil-to-lymphocyte ratio as a predictor of invasive carcinoma in patients with intraductal papillary mucinous neoplasms of the pancreas Journal Article

   


Authors: McIntyre, C. A.; Pulvirenti, A.; Lawrence, S. A.; Seier, K.; Gonen, M.; Balachandran, V. P.; Kingham, T. P.; D'Angelica, M. I.; Drebin, J. A.; Jarnagin, W. R.; Allen, P. J.
Article Title: Neutrophil-to-lymphocyte ratio as a predictor of invasive carcinoma in patients with intraductal papillary mucinous neoplasms of the pancreas
Abstract: Preoperative determination of the grade of dysplasia in intraductal papillary mucinous neoplasms (IPMNs) is necessary for optimal management. Previous data have suggested that serum neutrophil-to-lymphocyte ratio (NLR) can predict invasive disease in patients with IPMN. Methods A prospectively maintained database was queried for consecutive patients who underwent resection of IPMN. Exclusion criteria included recent diagnosis of cancer, immunosuppression, and infection or jaundice within 1 month of operation. A complete blood count with differential within 30 days of operation was used to calculate NLR. Results Within the study period, 446 patients underwent resection for IPMN, and 348 patients (78%) met the inclusion criteria. Low-grade dysplasia was present in 60 patients (17%), 137 patients (39%) had intermediate-grade dysplasia, 76 (22%) had high-grade dysplasia, and 75 (22%) had invasive carcinoma. A higher NLR was associated with invasive carcinoma as compared with noninvasive disease (3.00 vs 2.68, P = 0.039). There was no difference in NLR between patients with high-risk (invasive and high-grade) and low-risk (low-grade and intermediate-grade) lesions (2.80 vs 2.71, P > 0.95). Conclusions Neutrophil-to-lymphocyte ratio was significantly higher in patients with IPMN-associated invasive carcinoma as compared with patients with noninvasive disease; however, NLR was not helpful in differentiating between high- and low-grade lesions. © 2019 Wolters Kluwer Health, Inc. All rights reserved.
Keywords: intraductal papillary mucinous neoplasm; pancreatic cyst; neutrophil-to-lymphocyte ratio; ipmn-associated carcinoma
Journal Title: Pancreas
Volume: 48
Issue: 6
ISSN: 0885-3177
Publisher: Lippincott Williams & Wilkins  
Date Published: 2019-07-01
Start Page: 832
End Page: 836
Language: English
DOI: 10.1097/mpa.0000000000001342
PUBMED: 31210665
PROVIDER: scopus
PMCID: PMC7596842
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85067608913&doi=10.1097%2fMPA.0000000000001342&partnerID=40&md5=557d104b92b380b97e0d55471c0ac02a
Notes: Article -- Source: Scopus
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MSK Authors
  1. Mithat Gonen
    1028 Gonen
  2. Peter Allen
    501 Allen
  3. William R Jarnagin
    903 Jarnagin
  4. Michael D'Angelica
    777 D'Angelica
  5. T Peter Kingham
    609 Kingham
  6. Vinod P Balachandran
    251 Balachandran
  7. Kenneth Seier
    104 Seier
  8. Sharon Anita Lawrence
    15 Lawrence
  9. Jeffrey Adam Drebin
    165 Drebin
  10. Alessandra Pulvirenti
    30 Pulvirenti
  11. Caitlin Anne McIntyre
    39 McIntyre
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