Monitoring the safety of a smallpox vaccination program in the United States: Report of the joint Smallpox Vaccine Safety Working Group of the Advisory Committee on Immunization Practices and the Armed Forces Epidemiological Board Journal Article
| Authors: | Neff, J.; Modlin, J.; Birkhead, G. S.; Poland, G.; Robertson, R. M.; Sepkowitz, K.; Yancy, C.; Gardner, P.; Gray, G. C.; Maurer, T.; Siegel, J.; Guerra, F. A.; Berger, T.; Flanders, W. D.; Shope, R. |
| Article Title: | Monitoring the safety of a smallpox vaccination program in the United States: Report of the joint Smallpox Vaccine Safety Working Group of the Advisory Committee on Immunization Practices and the Armed Forces Epidemiological Board |
| Abstract: | In December 2002, the Centers for Disease Control and Prevention's Advisory Committee on Immunization Practices and the Department of Defense Armed Forces Epidemiological Board formed a joint Smallpox Vaccine Safety Working Group (SVS WG) to provide independent safety oversight for smallpox vaccination safety-monitoring systems. From January 2003 through June 2004, the SVS WG reviewed individual and aggregate safety data on postvaccination adverse events. Serious adverse events were rare because of careful education, prevaccination screening, and strict attention to vaccination-site management. Recent vaccinees safely cared for high-risk patients, adhering to recommended site care. Human immunodeficiency virus-infected individuals without severe immunosuppression had uncomplicated vaccination reactions. Epidemiological studies supported a causal relationship between myocarditis and/or pericarditis and smallpox vaccination. Data supported neutrality regarding hypothesized causal associations between vaccination and dilated cardiomyopathy or ischemic cardiac disease. The SVS WG concurs with recommendations to defer from vaccination any person with ≥3 ischemic cardiac disease risk factors. © 2008 by the Infectious Diseases Society of America. All rights reserved. |
| Keywords: | adolescent; adult; treatment response; aged; middle aged; retrospective studies; unclassified drug; disease course; fatigue; drug safety; united states; human immunodeficiency virus infection; clinical practice; myalgia; health survey; patient monitoring; retrospective study; risk assessment; arthralgia; backache; fever; pruritus; standard; government; patient care; disease severity; drug surveillance program; adverse drug reaction reporting systems; medical education; evaluation; vaccination; health care personnel; injection site pain; cidofovir; headache; immunosuppressive treatment; screening test; health personnel; inoculation; heart muscle ischemia; pericarditis; soldier; military personnel; stevens johnson syndrome; immunization; vaccinia; smallpox; swelling; smallpox vaccine; dryvax vaccine; congestive cardiomyopathy; myocarditis; mass immunization; sentinel surveillance; superinfection; vaccinia antibody; army; united states dept. of health and human services |
| Journal Title: | Clinical Infectious Diseases |
| Volume: | 46 |
| Issue: | Suppl. 3 |
| ISSN: | 1058-4838 |
| Publisher: | Oxford University Press |
| Date Published: | 2008-03-15 |
| Start Page: | S258 |
| End Page: | S270 |
| Language: | English |
| DOI: | 10.1086/524749 |
| PUBMED: | 18284367 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 12" - "Export Date: 17 November 2011" - "CODEN: CIDIE" - "Source: Scopus" |
