A prospective clinical trial of proton therapy for chordoma and chondrosarcoma: Feasibility assessment Journal Article

Authors: Baumann, B. C.; Lustig, R. A.; Mazzoni, S.; Grady, S. M.; O’Malley, B. W.; Lee, J. Y. K.; Newman, J. G.; Schuster, J. M.; Both, S.; Lin, A.; Dorsey, J. F.; Alonso-Basanta, M.
Article Title: A prospective clinical trial of proton therapy for chordoma and chondrosarcoma: Feasibility assessment
Abstract: Background/Objectives: Proton therapy (PRT) has emerged as a treatment option for chordomas/chondrosarcomas to escalate radiation dose more safely. We report results of a phase I/II trial of PRT in patients with chordoma/chondrosarcoma. Methods: Twenty adult patients with pathologically confirmed, nonmetastatic chordoma or chondrosarcoma were enrolled in a single-institution prospective trial of PRT from 2010 to 2014. Seventeen patients received adjuvant PRT and three received definitive PRT. Median dose was 73.8 Gy(RBE; range 68.4-79.2 Gy) using PRT-only (n = 6) or combination PRT/intensity-modulated radiotherapy (IMRT) (n = 14). Quality-of-life (QOL) and fatigue were assessed weekly and every 3 months posttreatment with the Functional Assessment of Cancer Therapy - Brain (FACTBr) and Brief Fatigue Inventory. Primary endpoint was feasibility (90% completing treatment with < 10 day treatment delay and ≤ 20% unexpected acute grade ≥ 3 toxicity). Results: Tumors included chordomas of the skull base (n = 10), sacrum (n = 5), and cervical spine (n = 3), and skull base chondrosarcomas (n = 2). Median age was 57. The 80% had positive margins/gross disease. Median follow-up was 37 months. Feasibility endpoints were met. The 3-year local control and progression-free survival was 86% and 81%. There were no deaths. Two patients had acute grade 3 toxicity (both fatigue). One had late grade 3 toxicity (epistaxis and osteoradionecrosis). There were no significant differences in patient reported fatigue or QOL from baseline to the end-of-treatment. Conclusions: We report favorable local control, survival, and toxicity following PRT. © 2019 Wiley Periodicals, Inc.
Keywords: chondrosarcoma; chordoma; proton therapy
Journal Title: Journal of Surgical Oncology
Volume: 120
Issue: 2
ISSN: 0022-4790
Publisher: Wiley Blackwell  
Date Published: 2019-08-01
Start Page: 200
End Page: 205
Language: English
DOI: 10.1002/jso.25502
PUBMED: 31111502
PROVIDER: scopus
Notes: Article -- Export Date: 2 August 2019 -- Source: Scopus
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