Arithmetic of vulnerable plaques for noninvasive imaging Journal Article
| Authors: | Narula, J.; Garg, P.; Achenbach, S.; Motoyama, S.; Virmani, R.; Strauss, H. W. |
| Article Title: | Arithmetic of vulnerable plaques for noninvasive imaging |
| Abstract: | Sudden cardiac death and acute myocardial infarction often occur as the first manifestation of coronary artery disease. Otherwise asymptomatic individuals with subclinical atherosclerosis almost always have a classic risk-factor profile and it is essential that they are identified before the occurrence of an acute coronary event. The ability to recognize such individuals requires the development of strategies that can localize unstable atherosclerotic lesions. Plaques that are vulnerable to rupture demonstrate distinct histological characteristics, including large plaque and necrotic core volumes, extensive remodeling of the vessel at the lesion site, and attenuated fibrous caps. Precise metrics of typical vulnerable atherosclerotic plaque dimensions will need to be defined to facilitate their identification by noninvasive imaging modalities. |
| Keywords: | vasculotropin; histopathology; nuclear magnetic resonance imaging; diagnostic accuracy; vascular cell adhesion molecule 1; tomography, x-ray computed; caspase; diagnostic imaging; risk assessment; contrast enhancement; acetylsalicylic acid; cardiovascular risk; heart death; acute heart infarction; echography; fluorodeoxyglucose f 18; fc receptor; symptomatology; hydroxymethylglutaryl coenzyme a reductase inhibitor; atherosclerotic plaque; coronary artery atherosclerosis; coronary artery disease; non invasive procedure; neovascularization (pathology); intercellular adhesion molecule 1; hla antigen; monocyte chemotactic protein 1; myocardial infarction; computed tomographic angiography; metalloproteinase; ultrasonography, interventional; multidetector computed tomography; optical coherence tomography; sudden death; tissue necrosis; vitronectin receptor; percutaneous coronary intervention; coronary angiography; acute coronary syndrome; phosphatidylserine; coronary stent; selectin; scavenger receptor a; intravascular ultrasound; death, sudden, cardiac |
| Journal Title: | Nature Clinical Practice Cardiovascular Medicine |
| Volume: | 5 |
| Issue: | SUPPL. 2 |
| ISSN: | 1743-4297 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2008-08-01 |
| Start Page: | S2 |
| End Page: | S10 |
| Language: | English |
| DOI: | 10.1038/ncpcardio1247 |
| PUBMED: | 18641603 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 46" - "Export Date: 17 November 2011" - "Source: Scopus" |
