Thyroid cancer bone metastasis: Survival and genomic characteristics of a large tertiary care cohort Journal Article

   

Authors:	Kondraciuk, J. D.; Rice, S. L.; Zhou, X.; Gharzeddine, K.; Knezevic, A.; Spratt, D. E.; Sabra, M.; Larson, S. M.; Grewal, R. K.; Osborne, J. R.
Article Title:	Thyroid cancer bone metastasis: Survival and genomic characteristics of a large tertiary care cohort
Abstract:	Purpose Bone metastasis (BM) in differentiated thyroid cancer (DTC) is the second most common site of metastasis after lung. Bone metastases are associated with worse prognosis in DTC. In this study, we examined risk factors for overall survival in patients with BM and for the first time explore the pattern of genomic alterations in DTC BM. Patients and Methods A Health Insurance Portability and Accountability Act (HIPAA) compliant, institutional review board-approved retrospective evaluation of the medical record was performed for all patients treated at a single institution for thyroid cancer over a 16-year period. Seventy-four patients met inclusion criteria. Multiple prognostic factors including age, sex, genes, radioactive iodine, and radiation or kinase inhibitor therapies were analyzed. Univariate and multivariate analyses were performed. Results Treatment with external beam radiation was found to significantly increase survival (P = 0.03). The 5-year survival rate was 59% and median survival was 92 months. Patients who developed bone metastasis earlier tend to live longer (P = 0.06). The presence of TERT and BRAF mutations did not significantly worsen the prognosis (P = 0.10). Conclusion Patients with DTC can benefit from early treatment with external beam radiation therapy, especially those who develop bone metastasis within 3 years of primary TC diagnosis. Kinase inhibitor treatment tended to prolong survival but not in a statistically significant manner. Sex, age, and TERT or BRAF genetic mutations did not significantly affect the prognosis. © Wolters Kluwer Health, Inc. All rights reserved.
Keywords:	adult; cancer survival; aged; survival rate; gene mutation; major clinical study; overall survival; bone metastasis; cancer radiotherapy; retrospective study; risk factor; iodine 131; telomerase reverse transcriptase; ras protein; external beam radiotherapy; b raf kinase; phosphotransferase inhibitor; differentiated thyroid cancer; external beam radiation; cancer prognosis; genomic characteristics; human; male; female; article; median survival time; thyroid cancer bone metastasis
Journal Title:	Clinical Nuclear Medicine
Volume:	44
Issue:	8
ISSN:	0363-9762
Publisher:	Lippincott Williams & Wilkins
Date Published:	2019-08-01
Start Page:	e465
End Page:	e471
Language:	English
DOI:	10.1097/rlu.0000000000002626
PUBMED:	31274625
PROVIDER:	scopus
PMCID:	PMC6621602
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85069269656&doi=10.1097%2fRLU.0000000000002626&partnerID=40&md5=03f2532d8a51522ccabf99c4f640768d
Notes:	Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/150138