Impact of age on clinical risk scores in follicular lymphoma Journal Article


Authors: Alig, S.; Jurinovic, V.; Pastore, A.; Haebe, S.; Schmidt, C.; Zoellner, A. K.; Dreyling, M.; Unterhalt, M.; Hoster, E.; Hiddemann, W.; Weigert, O.
Article Title: Impact of age on clinical risk scores in follicular lymphoma
Abstract: The Follicular Lymphoma (FL) International Prognostic Index (FLIPI) and FLIPI-2 are well-described clinical risk models. Age .60 years at diagnosis is a risk factor in both scores. Recently, we showed that older age is not associated with higher risk of disease progression or inferior treatment efficacy. Instead, shorter survival of older patients results mainly from an increased risk of nonrelapse deaths. This questions the value of age as a meaningful component of scores intended to predict disease-specific survival. The newly proposed PRIMA-prognostic index (PRIMA-PI) only includes b2-microglobulin levels and bone marrow infiltration as risk factors. Here, we independently validate the PRIMA-PI in a clinical trial cohort of 475 patients with advanced FL who uniformly received cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, prednisone, and rituximab (R-CHOP) as frontline therapy. The PRIMA-PI separated 3 similar sized risk cohorts with 5-year progression-free survival (PFS) rates of 74%, 59%, and 39%, respectively (P, .0001). Furthermore, we compare the PRIMA-PI with the FLIPI and FLIPI-2. We demonstrate that the PRIMA-PI has the highest specificity to identify high-risk patients (80% for 5-year PFS) because of its superior risk stratification in patients .60 years (73% vs 33% [FLIPI] and 47% [FLIPI-2] for 5-year PFS). Thus, the PRIMA-PI is a promising clinical tool to stringently identify patients at highest risk of poor outcome after frontline R-CHOP for advanced FL, and is particularly useful in patients with older age. Further validation in non–R-CHOP treated cohorts is needed. © 2019 by The American Society of Hematology.
Keywords: adult; cancer survival; treatment outcome; middle aged; major clinical study; overall survival; advanced cancer; progression free survival; cohort analysis; high risk patient; age; risk assessment; follicular lymphoma; instrument validation; cancer prognosis; follicular lymphoma international prognostic index; human; priority journal; article; prognostic assessment; cyclophosphamide plus doxorubicin plus prednisolone plus rituximab plus vincristine; prima prognostic index
Journal Title: Blood Advances
Volume: 3
Issue: 7
ISSN: 2473-9529
Publisher: American Society of Hematology  
Date Published: 2019-04-09
Start Page: 1033
End Page: 1038
Language: English
DOI: 10.1182/bloodadvances.2019032136
PUBMED: 30940638
PROVIDER: scopus
PMCID: PMC6457218
DOI/URL:
Notes: Article -- Export Date: 2 August 2019 -- Source: Scopus
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  1. Alessandro   Pastore
    31 Pastore