Authors: | Ling, C. C.; Sahoo, N.; Leibel, S.; Anderson, L. L. |
Article Title: | High dose rate gynecological applications - Fadiobiological considerations based on the α-β model |
Abstract: | We compare the relative efficacy of high dose rate (HDR) and low dose rate (LDR) irradiation in gynecological implants, using formulations based on the linear-quadratic (α-β) model. We consider both acute reaction and late effect as endpoints in evaluating equivalence for HDR and LDR treatments, at Point A (as defined in the text) and at other locations. We define a therapeutic factor Γ as an index for relative efficacy, with Γ > 1 indicating a gain in substituting HDR for LDR. It is found that Γ < 1 for most clinical situations, although a modest decrease (of about 15%) in dose to critical organs for HDR would raise Γ above unity. © 1992. |
Keywords: | comparative study; radiation dose; linear models; radiotherapy dosage; dose-response relationship, radiation; genital neoplasms, female; brachytherapy; gynecologic cancer; linear-quadratic model; human; female; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; brachytherapy radiobiology; high dose rate intracavitary implant |
Journal Title: | Radiotherapy and Oncology |
Volume: | 25 |
Issue: | 2 |
ISSN: | 0167-8140 |
Publisher: | Elsevier Inc. |
Date Published: | 1992-10-01 |
Start Page: | 103 |
End Page: | 110 |
Language: | English |
DOI: | 10.1016/0167-8140(92)90016-n |
PUBMED: | 1438929 |
PROVIDER: | scopus |
DOI/URL: | |
Notes: | Source: Scopus |