High dose rate gynecological applications - Fadiobiological considerations based on the α-β model Journal Article


Authors: Ling, C. C.; Sahoo, N.; Leibel, S.; Anderson, L. L.
Article Title: High dose rate gynecological applications - Fadiobiological considerations based on the α-β model
Abstract: We compare the relative efficacy of high dose rate (HDR) and low dose rate (LDR) irradiation in gynecological implants, using formulations based on the linear-quadratic (α-β) model. We consider both acute reaction and late effect as endpoints in evaluating equivalence for HDR and LDR treatments, at Point A (as defined in the text) and at other locations. We define a therapeutic factor Γ as an index for relative efficacy, with Γ > 1 indicating a gain in substituting HDR for LDR. It is found that Γ < 1 for most clinical situations, although a modest decrease (of about 15%) in dose to critical organs for HDR would raise Γ above unity. © 1992.
Keywords: comparative study; radiation dose; linear models; radiotherapy dosage; dose-response relationship, radiation; genital neoplasms, female; brachytherapy; gynecologic cancer; linear-quadratic model; human; female; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; brachytherapy radiobiology; high dose rate intracavitary implant
Journal Title: Radiotherapy and Oncology
Volume: 25
Issue: 2
ISSN: 0167-8140
Publisher: Elsevier Inc.  
Date Published: 1992-10-01
Start Page: 103
End Page: 110
Language: English
DOI: 10.1016/0167-8140(92)90016-n
PUBMED: 1438929
PROVIDER: scopus
DOI/URL:
Notes: Source: Scopus
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MSK Authors
  1. Steven A Leibel
    252 Leibel
  2. C Clifton Ling
    331 Ling