Transforming growth factor β induces myoblast differentiation in the presence of mitogens Journal Article
| Authors: | Zentella, A.; Massagué, J. |
| Article Title: | Transforming growth factor β induces myoblast differentiation in the presence of mitogens |
| Abstract: | Transforming growth factor β1 (TGF-β1) added to L6E9 rat skeletal myoblasts in mitogen-rich medium induces a rapid decrease in c-myc expression and delays progression through the G1 phase of the cell cycle. This growth inhibitory response is followed by cell commitment to terminal differentiation with elevated expression of myogenin muscle determination genes, induction of muscle-specific proteins, and formation of multinucleated myotubes. These results suggest that TGF-β1 may act as a physiological inducer of myogenic differentiation in mitogen-rich environments, and its otherwise reversible growth inhibitory effect may become permanent if coupled to induction of terminal differentiation. |
| Keywords: | controlled study; nonhuman; animal cell; animal; cells, cultured; cell cycle; gene expression; transforming growth factor beta; cell differentiation; animalia; molecular sequence data; rna, messenger; genes, myc; rat; base sequence; down regulation; creatine kinase; rats; oncogene c myc; cell cycle g1 phase; skeletal muscle; in vitro; myoblast; muscles; growth inhibition; mitogenic agent; mitogens; muscle development; myogenesis; muscle protein; priority journal; article |
| Journal Title: | Proceedings of the National Academy of Sciences of the United States of America |
| Volume: | 89 |
| Issue: | 11 |
| ISSN: | 0027-8424 |
| Publisher: | National Academy of Sciences |
| Date Published: | 1992-06-01 |
| Start Page: | 5176 |
| End Page: | 5180 |
| Language: | English |
| DOI: | 10.1073/pnas.89.11.5176 |
| PUBMED: | 1594628 |
| PROVIDER: | scopus |
| PMCID: | PMC49252 |
| DOI/URL: | |
| Notes: | Source: Scopus |
