Induction by estrogen metabolite 16α-hydroxyestrone of genotoxic damage and aberrant proliferation in mouse mammary epithelial cells Journal Article

  


Authors: Telang, N. T.; Suto, A.; Wong, G. Y.; Osborne, M. P.; Bradlow, H. L.
Article Title: Induction by estrogen metabolite 16α-hydroxyestrone of genotoxic damage and aberrant proliferation in mouse mammary epithelial cells
Abstract: Background: Estrogens are potent mammary tumor promoters influencing post-initiational events via epigenetic mechanisms. The upregulation (i.e., induction) of the C16α-hydroxylation pathway during 17β-estradiol (E2) biotransformation has been associated with mammary cell transformation. The action of E2 metabolites on tumorigenic transformation, however, is poorly understood. Purpose: The newly established mammary epithelial cell line C57/MG, derived from the C57BL mouse strain, was used to examine whether E2 or its metabolites, 16-hydroxyestrone (16α-OHE1) and estriol (E3), function as initiators of mammary cell transformation. Methods: DNA repair (hydroxyurea-insensitive thymidine uptake), estrogen metabolism (3H exchange to form 3H20), hyperproliferation (increased cell number), and acquisition of anchorage-independent © 1992 Oxford University Press.
Keywords: controlled study; nonhuman; dna synthesis; animal cell; mouse; animal; mice; cell division; dna repair; cell growth; estrogen; tumor cells, cultured; mice, inbred c57bl; cell transformation, neoplastic; dimethyl sulfoxide; cell transformation; carcinogenicity; breast epithelium; estrogen receptor; estradiol; genotoxicity; mammary neoplasms, experimental; hydroxylation; estrogen metabolism; female; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; dimethylbenz[a]anthracene; 16alpha hydroxyestrone; estriol; hydroxyestrones
Journal Title: JNCI: Journal of the National Cancer Institute
Volume: 84
Issue: 8
ISSN: 0027-8874
Publisher: Oxford University Press  
Date Published: 1992-04-15
Start Page: 634
End Page: 638
Language: English
DOI: 10.1093/jnci/84.8.634
PUBMED: 1556774
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0026582407&doi=10.1093%2fjnci%2f84.8.634&partnerID=40&md5=c6282b1d3638c1a839f03d1cf22a1f19
Notes: Source: Scopus
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MSK Authors
  1. George Y. Wong
    89 Wong
  2. Michael P. Osborne
    61 Osborne
  3. Nitin Telang
    29 Telang
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