p53 gene mutations in primary lung tumors are conserved in brain metastases Journal Article
| Authors: | Schlegel, U.; Rosenfeld, M. R.; Volkenandt, M.; Rosenblum, M.; Dalmau, J.; Furneaux, H. |
| Article Title: | p53 gene mutations in primary lung tumors are conserved in brain metastases |
| Abstract: | The p53 product is frequently mutated in human tumors. Both acquired and inherited mutations have been described. These mutations transform p53 from a growth suppressor gene to a transforming oncogene. We examined tissue from 6 patients with primary lung carcinoma and the corresponding brain metastases for the presence of p53 mutations by immunohistochemistry. We then confirmed and characterized the mutations by single strand conformation analysis and by direct sequence analysis. All 6 patients had primary and metastatic tumor expressing a mutant p53. The mutations were all G-T transversions and mapped to exons 5, 6, 7, and 8. The mutations in the primary tumors were precisely conserved in the brain metastases. © 1992 Kluwer Academic Publishers. |
| Keywords: | adult; clinical article; controlled study; human tissue; aged; mutation; exons; comparative study; brain neoplasms; polymerase chain reaction; gene expression; carcinoma, non-small-cell lung; lung neoplasms; lung tumor; molecular sequence data; dna, neoplasm; brain metastasis; base sequence; dna mutational analysis; molecular biology; codon; p53; genes, p53; middle age; lung tumors; human; male; female; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s. |
| Journal Title: | Journal of Neuro-Oncology |
| Volume: | 14 |
| Issue: | 2 |
| ISSN: | 0167-594X |
| Publisher: | Springer |
| Date Published: | 1992-10-01 |
| Start Page: | 93 |
| End Page: | 100 |
| Language: | English |
| DOI: | 10.1007/bf00177612 |
| PUBMED: | 1331352 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
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57Furneaux -
424Rosenblum -
101
Dalmau -
36
Rosenfeld -
27Volkenandt
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