P-glycoprotein expression in brain tumors Journal Article

  


Authors: Henson, J. W.; Cordon-Cardo, C.; Posner, J. B.
Article Title: P-glycoprotein expression in brain tumors
Abstract: Overexpression of P-glycoprotein (P-gp) in cancer cells can result in resistance to several chemotherapy agents (multidrug resistance) including doxorubicin and vincristine. The drugs to which resistance develops also penetrate the blood brain barrier poorly. P-gp expression in brain capillary endothelial cells suggests that P-gp may restrict drug entry into brain tumors and thus be another mechanism of drug resistance. To seek evidence for either of these roles in the drug resistance of brain tumors, we examined the location of expression of P-gp in 49 brain tumors, using an anti-P-gp mouse monoclonal antibody and immunohistochemistry. P-gp expression was observed in tumor cells of two glioblastomas and a meningeal sarcoma but not in low-grade primary or metastatic tumors. In low-grade primary tumors, P-gp was present in all vascular endothelial cells. In the vascular endothelial cells of anaplastic primary brain tumors and brain metastases, P-gp expression was heterogeneous or absent. These findings are consistent with a role for P-gp in the resistance of some brain tumors to chemotherapy agents. © 1992 Kluwer Academic Publishers.
Keywords: immunohistochemistry; human tissue; doxorubicin; antineoplastic agents; brain tumor; glioma; brain neoplasms; neoplasm proteins; vincristine; drug resistance; antibodies, monoclonal; endothelium, vascular; membrane glycoproteins; glioblastoma; cell membrane; blood-brain barrier; brain metastasis; multidrug resistance; p-glycoprotein; glycoprotein p; human; article
Journal Title: Journal of Neuro-Oncology
Volume: 14
Issue: 1
ISSN: 0167-594X
Publisher: Springer  
Date Published: 1992-09-01
Start Page: 37
End Page: 43
Language: English
DOI: 10.1007/bf00170943
PUBMED: 1361524
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0026800836&doi=10.1007%2fBF00170943&partnerID=40&md5=51eb1a7e515dbb1b67e167e6075a67de
Notes: Carlos Cordon-Cardo's affiliation is incomplete on the origianl publication -- Source: Scopus
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MSK Authors
  1. Carlos Cordon-Cardo
    612 Cordon-Cardo
  2. Jerome B Posner
    211 Posner
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