Quantitation of total metastatic tumor volume in the rat liver: Correlation of MR and histologic measurements Journal Article


Authors: Mahmood, U.; Devitt, M. L.; Kocheril, P. G.; Sutanto‐Ward, E.; Ballon, D.; Sigurdson, E. R.; Koutcher, J. A.
Article Title: Quantitation of total metastatic tumor volume in the rat liver: Correlation of MR and histologic measurements
Abstract: Assessing tumor response to chemotherapy in the liver has always been difficult. Most investigators estimate tumor volume as either a product of the two perpendicular diameters of a tumor nodule, or, in animal studies, simply count surface tumor nodules. The authors evaluated magnetic resonance (MR) imaging as a technique for determining absolute tumor volume in the liver in an animal model. Specifically, histologic volumetric and MR imaging measurements of tumor and liver volumes were quantitatively compared over a wide range of tumor burdens in a rat model of hepatic metastasis of a colorectal carcinoma. Twenty‐three rats were imaged, with two different section thicknesses used in each animal. Both section thicknesses showed highly significant correlations between MR and histologic measurements for both tumor and liver volumes (P <.001). MR imaging may be useful for noninvasively quantifying tumor burden and temporal response of metastatic disease in the liver to novel antineoplastic regimens. Copyright © 1992 Wiley‐Liss, Inc., A Wiley Company
Keywords: liver neoplasms; comparative study; nuclear magnetic resonance imaging; magnetic resonance imaging; adenocarcinoma; animal; metastasis; pathology; liver tumor; rat; rats; neoplasm transplantation; cancer transplantation; comparative studies; article; volume measurement; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; liver neoplasms, mr, 761.33; liver neoplasms, secondary, 761.33; liver, mr, 761.1214
Journal Title: Journal of Magnetic Resonance Imaging
Volume: 2
Issue: 3
ISSN: 1053-1807
Publisher: Wiley Blackwell  
Date Published: 1992-05-01
Start Page: 335
End Page: 340
Language: English
DOI: 10.1002/jmri.1880020314
PUBMED: 1627869
PROVIDER: scopus
DOI/URL:
Notes: Article -- Source: Scopus
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
  1. Douglas J Ballon
    49 Ballon
  2. Jason A Koutcher
    278 Koutcher
  3. Mary Louise Devitt
    5 Devitt
  4. Umar Mahmood
    11 Mahmood