Precancerous lesions of the human esophagus: Multiparameteric study of esophageal biopsies from a high‐risk population in Linxian, China Conference Paper

  


Authors: Yang, K.; Liu, Y.; Lipkin, M.; Wang, G.; Mou, D.; Li, G.; Li, J.; Li, P.
Title: Precancerous lesions of the human esophagus: Multiparameteric study of esophageal biopsies from a high‐risk population in Linxian, China
Conference Title: Intermediate Biomarkers of Precancer and Their Application in Chemoprevention
Abstract: Histopathology, morphometry, tritiated thymidin incorporation and immunohistochemistry were studied in 221 esophageal biospies from subjects with cytologica hyperplasia in Linxian, China. A spectrum of 7 morphologic entities were found (1) normal/near normal (NN); (2) basal cell hyperplasia 0 (BHO); (3) simple hyperplasia (SH); (4) mixed basal and spinous cell hyperplasia (MBS); (5) basal cell hyperplasia 1 (BH1); (6) dysplasia (D); and (7) non‐profilerative lesion (NP). Forty percent of the biospies had combinations of histologic types. The thickness of the epithelium was increased in SH, MBS, and BH1, but not in BHO and NP Elongation of papiallae was frequent seen in SH, MBS, BH1, and D. Papillary bleeding was very prevalent in the esophageal specimens studied. A variety of cellular changes were found in peripapillary areas especially when bleeding occurred. [ 3 H]‐thymidine labeling index was dramatically increased in the entire epithelium in dysplasia, and also increased in cell layer 3 of MBS, BH1 and D. Blood group antigen Le Y and lectin WGA showed consistent positivity in cellular membranes of the squamous cells, and these changes ocuurred before gross morphologic alterations. These findings provide a hypothesis for the sequences of pathogenetic events leading to esophgeal carcinoma, and define each step with corresponding biomakers for cancer prevention studies. © 1992 Wiley‐Liss, Inc. Copyright © 1992 Wiley‐Liss, Inc.
Keywords: human tissue; major clinical study; conference paper; cytology; metabolism; cell cycle; chemoprophylaxis; biological model; models, biological; risk factors; pathology; tumor marker; risk factor; biopsy; enzyme immunoassay; immunoenzyme techniques; kinetics; epithelium cell; epithelial cells; epithelium; esophagus cancer; esophagus; esophagus tumor; esophageal neoplasms; thymidine; china; esophagus biopsy; tritium; precancerous conditions; chemoprevention; mitosis index; mitotic index; lectin; precancer; precancerous lesions; lectins; wheat germ agglutinin; triticum aestivum; human; priority journal; article; protective agent; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; blood group antigen; intermediate biomaker; le y; wga
Journal Title Journal of Cellular Biochemistry
Volume: 50
Issue: Suppl. 16G
Conference Dates: 1991 Oct 3-7
Conference Location: Keystone, CO
ISBN: 0730-2312
Publisher: John Wiley & Sons  
Date Published: 1992-01-01
Start Page: 187
End Page: 194
Language: English
DOI: 10.1002/jcb.240501132
PUBMED: 1469900
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027033761&doi=10.1002%2fjcb.240501132&partnerID=40&md5=28e490fb75a14174421012f3edc65df6
Notes: Article -- Source: Scopus
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MSK Authors
  1. Martin Lipkin
    116 Lipkin
  2. Kan Yang
    24 Yang
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