Efficacy of cisplatin-based intraperitoneal chemotherapy as treatment of malignant peritoneal mesothelioma Journal Article
| Authors: | Markman, M.; Kelsen, D. |
| Article Title: | Efficacy of cisplatin-based intraperitoneal chemotherapy as treatment of malignant peritoneal mesothelioma |
| Abstract: | In an effort to examine the potential clinical utility of intraperitoneal (i.p.) therapy in the management of patients with malignant peritoneal mesothelioma, 19 individuals with this disease were treated with a cisplatinbased i.p. treatment regimen. All but 1 patient also received i.p. mitomycin. The treatment was generally well tolerated, although a maximum of only four or five courses of cisplatin (100 mg/m2 every 28 days) and mitomycin (5-10 mg/treatment given 7 days after each i.p. cisplatin administration) could be administered, the treatment principally being stopped because of disease progression or catheter failure. Of 15 patients with malignant ascites, 7 (47%) experienced control of fluid reaccumulation ranging from 2 months to 73+ months (median 8 months). While the median survival for the 19 patients was only 9 months, 4 (21%) patients survived for more than 3 years from the initiation of therapy, and 2 patients are currently alive and clinically disease-free more than 5 years from the start of the i.p. treatment program. We conclude that a subset of patients with peritoneal mesothelioma, principally those with small-volume residual disease following surgical tumor debulking, can benefit from a cisplatin-based i.p. treatment strategy with control of ascites and prolonged disease-free survival. © 1992 Springer-Verlag. |
| Keywords: | adult; clinical article; aged; survival analysis; cisplatin; peritoneal neoplasms; antineoplastic combined chemotherapy protocols; mesothelioma; mitomycin c; mitomycin; peritoneum mesothelioma; infusions, parenteral; intraperitoneal chemotherapy; peritoneal mesothelioma; middle age; peritonitis; intraperitoneal drug administration; mitomycins; human; male; female; article |
| Journal Title: | Journal of Cancer Research and Clinical Oncology |
| Volume: | 118 |
| Issue: | 7 |
| ISSN: | 0171-5216 |
| Publisher: | Springer |
| Date Published: | 1992-07-01 |
| Start Page: | 547 |
| End Page: | 550 |
| Language: | English |
| DOI: | 10.1007/bf01225271 |
| PUBMED: | 1624547 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
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