Expression of Her2/neu oncogene product p185 in correlation to clinicopathological and prognostic factors of gastric carcinoma Journal Article
| Authors: | Jaehne, J.; Urmacher, C.; Thaler, H. T.; Friedlander-Klar, H.; Cordon-Cardo, C.; Meyer, H. J. |
| Article Title: | Expression of Her2/neu oncogene product p185 in correlation to clinicopathological and prognostic factors of gastric carcinoma |
| Abstract: | The expression of the Her2/neu gene product p 185 was retrospectively analyzed in 58 patients with gastric carcinoma. The results were correlated to various clinicopathological and prognostic factors. Positive membrane staining for p185 could be detected in 38% of the patients (22/58). Membrane staining was significantly greater in well and moderately differentiated tumors of the intestinal type when compared with poorly differentiated lesions and carcinomas of the diffuse type (P<0.01). Positive membrane staining did not correlate with site and tumor stage, but T1 lesions had less membrane staining than more advanced primary tumors. Overall survival showed no difference between p185-positive and negative cases. Multivariate analysis defined a subgroup of curatively resected patients with stage III and IV disease that had a statistically significant poorer survival when p185 was overexpressed (P=0.005). Overexpression of the Her2/neu product p185 appears to be associated with intestinal-type gastric carcinoma and may sociated with intestinal-type gastric carcinoma and may help in identifying a subset of patients at increased risk for shorter survival. © 1992 Springer-Verlag. |
| Keywords: | immunohistochemistry; adult; human tissue; aged; retrospective studies; oncoprotein; major clinical study; proto-oncogene proteins; follow-up studies; adenocarcinoma; gene expression; tumor markers, biological; time factors; oncogene; receptor, erbb-2; stomach carcinoma; stomach neoplasms; proto-oncogenes; gastric carcinoma; prognosis; human; male; female; article; support, non-u.s. gov't; clinicopathological variables; her2/neu oncogene product p185 |
| Journal Title: | Journal of Cancer Research and Clinical Oncology |
| Volume: | 118 |
| Issue: | 6 |
| ISSN: | 0171-5216 |
| Publisher: | Springer |
| Date Published: | 1992-06-01 |
| Start Page: | 474 |
| End Page: | 479 |
| Language: | English |
| DOI: | 10.1007/bf01629433 |
| PUBMED: | 1352299 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
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45Urmacher
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