Microtubule active agents: Beyond the taxane frontier Journal Article
| Authors: | Morris, P. G.; Fornier, M. N. |
| Article Title: | Microtubule active agents: Beyond the taxane frontier |
| Abstract: | Microtubules are essential to cell transport, signaling, and mitosis. An increasing range of anticancer drugs interferes with the normal formation and function of microtubules. Vinca alkaloids act as microtubule destabilizers and the taxanes act as microtubule stabilizers. Taxanes are widely used cytotoxic agents that are active in a range of solid tumor malignancies and are routinely used in a variety of settings. Significant limitations with the taxanes exist, including acquired and intrinsic tumor resistance through the expression of multidrug resistance proteins such as P-glycoprotein, risk of hypersensitivity reactions, dose-limiting hematopoietic toxicity, and cumulative neurotoxicity. Hence, there is a need to develop novel agents that act on the microtubules. Epothilones are macrolide antibiotics that bind near the taxane-binding site on microtubules and have been extensively studied in recent and ongoing clinical trials. A variety of other agents that act on the microtubules at different sites with a variety of structures are at varying stages of development. ©2008 American Association for Cancer Research. |
| Keywords: | signal transduction; unclassified drug; clinical trial; drug activity; fatigue; neutropenia; review; bevacizumab; doxorubicin; advanced cancer; diarrhea; drug potentiation; nonhuman; recommended drug dose; solid tumor; antineoplastic agents; clinical trials as topic; capecitabine; gemcitabine; paclitaxel; pancreas cancer; neurotoxicity; glioma; antineoplastic agent; neoplasm; neoplasms; mitosis; animal; animals; imatinib; carboplatin; unindexed drug; melanoma; metastasis; lung toxicity; ovary cancer; sensory neuropathy; breast cancer; bone marrow suppression; blood toxicity; lung non small cell cancer; peripheral neuropathy; cyclophosphamide; antineoplastic activity; drug effect; bladder cancer; drug hypersensitivity; prostate cancer; drug mechanism; head and neck cancer; brain metastasis; binding site; taxoids; taxane derivative; trastuzumab; cell transport; esophagus cancer; microtubule; microtubules; drug binding; tumor resistance; drug delivery system; ixabepilone; sagopilone; 21 aminoepothilone b; 9,10 didehydroepothilone d; abj 879; epothilone b; epothilone d; epothilone derivative; tubulin modulator; tubulin modulators; paclitaxel poliglumex; taxoid; estramustine; cremophor; cyclostreptin; dictyostatin; discodermolide; eleutherobin; human albumin; laulimalide; peloruside a; creutzfeldt jakob disease |
| Journal Title: | Clinical Cancer Research |
| Volume: | 14 |
| Issue: | 22 |
| ISSN: | 1078-0432 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2008-11-15 |
| Start Page: | 7167 |
| End Page: | 7172 |
| Language: | English |
| DOI: | 10.1158/1078-0432.ccr-08-0169 |
| PUBMED: | 19010832 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 40" - "Export Date: 17 November 2011" - "CODEN: CCREF" - "Source: Scopus" |
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