Preferential killing of glucose-depleted hela cells by menadione and hyperthermia Journal Article

  


Authors: Kim, J. H.; Kim, S. H.; Dutta, P.; Pinto, J.
Article Title: Preferential killing of glucose-depleted hela cells by menadione and hyperthermia
Abstract: Energy deprivation of cancer cells increases sensitivity to killing by hyperthermia. Recent cell culture studies suggest that certain naphthoquinones, especially menadione (vitamin K3), have anti-tumour activity by interfering with the energy metabolism of cells, resulting in the inhibition of aerobic glycolysis. We therefore studied the cytotoxic effects of menadione in HeLa cells in combination with hyperthermia. The cell culture data show that the cytotoxicity is markedly increased in cells deprived of glucose in the medium at 37°c after exposure to menadione. When cells were exposed to menadione (20-40 μM) and hyperthermia (41-42°c), there was a dramatic potentiation of heat-induced cytotoxicity in cells deprived of glucose in the medium. These data suggest that glucose-deficient cancer cells could be selectively killed by the combined treatment of menadione and mild hyperthermia, both of which can be readily achievable in humans. © 1992 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
Keywords: human cell; cell death; cell survival; cytotoxicity; hela cell; hela cells; cell culture; glucose; hyperthermia; energy metabolism; glutathione; cell killing; menadione; heat; heat sensitivity; human; article; glutathione metabolism; vitamin k; glucose deprivation
Journal Title: International Journal of Hyperthermia
Volume: 8
Issue: 1
ISSN: 0265-6736
Publisher: Taylor & Francis Group  
Date Published: 1992-01-01
Start Page: 139
End Page: 146
Language: English
DOI: 10.3109/02656739209052886
PUBMED: 1545160
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0026528781&doi=10.3109%2f02656739209052886&partnerID=40&md5=7f8cc58d9e23e94e6a5e594ff832c0a2
Notes: Article -- Export Date: 30 July 2019 -- Source: Scopus
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MSK Authors
  1. John Pinto
    59 Pinto
  2. Purabi Dutta
    28 Dutta
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