Sinonasal small cell neoplasm developing after radiation therapy for retinoblastoma: An immunohistologic, ultrastructural, and cytogenetic study Journal Article
| Authors: | Saw, D.; Chan, J. K. C.; Jagirdar, J.; Greco, M. A.; Lee, M. |
| Article Title: | Sinonasal small cell neoplasm developing after radiation therapy for retinoblastoma: An immunohistologic, ultrastructural, and cytogenetic study |
| Abstract: | Patients with retinoblastoma have an increased risk of developing second primary tumors. Only a few examples of sinonasal small cell neoplasms developing after radiation therapy for retinoblastoma have been reported. We report one such case that developed 18 years after treatment for retinoblastoma. Histologic examination revealed a small, blue, round cell tumor without rosettes or cytoplasmic glycogen. Immunohistochemically, the tumor cells were positive for neuron-specific enolase, synaptophysin, and S-100 protein, but negative for epithelial and mesenchymal markers, suggesting that this was a primitive neuroectodermal tumor. Cytogenetic studies of this tumor failed to reveal the chromosome 13 abnormality typical of retinoblastoma and the t(11:22) translocation typical of the group of peripheral neuroepitheliomas. © 1992. |
| Keywords: | immunohistochemistry; adult; human tissue; case report; cancer radiotherapy; electron microscopy; microscopy, electron; radiation; cytogenetics; retinoblastoma; chromosome aberration; neoplasms, radiation-induced; dna, neoplasm; cytoplasm; chromosome translocation; protein s 100; neoplasms, second primary; chromosome aberrations; chromosome 13; neuroectoderm tumor; paranasal sinus neoplasms; nose tumor; radiation carcinogenesis; small cell carcinoma; s100 proteins; carcinoma, small cell; neuron specific enolase; synaptophysin; cell ultrastructure; glycogen; eye neoplasms; chromosome disorders; human; female; priority journal; article; translocation (genetics); sinonasal neoplasm |
| Journal Title: | Human Pathology |
| Volume: | 23 |
| Issue: | 8 |
| ISSN: | 0046-8177 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1992-08-01 |
| Start Page: | 896 |
| End Page: | 899 |
| Language: | English |
| DOI: | 10.1016/0046-8177(92)90401-n |
| PUBMED: | 1322860 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 30 July 2019 -- Source: Scopus |
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