Evaluation of new anti-infective drugs for the treatment of febrile episodes in neutropenic patients Journal Article
| Authors: | Hughes, W. T.; Pizzo, P. A.; Wade, J. C.; Armstrong, D.; Webb, C. D.; Young, L. S. |
| Article Title: | Evaluation of new anti-infective drugs for the treatment of febrile episodes in neutropenic patients |
| Abstract: | The use of empirical antimicrobial therapy has significantly reduced the morbidity and mortality associated with untreated infections in febrile neutropenic patients. This guideline describes clinical trials of the safety and efficacy of new antimicrobial drugs in this population of patients. Fever and neutropenia should be precisely defined in each protocol. Patients should be randomized to treatment with a new or active-control drug regimen, stratified on the basis of type of cancer and age, and treated until resolution-as defined in the protocol-is attained. Outcome should be assessed both for cases with a defined microbial etiology and for those without. Final microbiological outcome is important for cases with identified pathogens, but clinical outcome is paramount. © 1992 Oxford University Press. |
| Keywords: | clinical trial; neutropenia; review; drug efficacy; drug safety; patient selection; research design; infection; granulocyte macrophage colony stimulating factor; drug screening; age; fever; standard; cytokine; clinical protocols; randomization; microbiology; penicillin derivative; candidiasis; cytomegalovirus infection; aspergillosis; clinical trials; intravenous drug administration; antimicrobial therapy; oral drug administration; anti-infective agents; cephalosporin derivative; carbapenem; aminoglycoside antibiotic agent; gram negative infection; monobactam derivative; quinolone derivative; clinical trials, phase ii; clinical trials, phase iii; clinical trials, phase i; human; priority journal; beta lactam antibiotic; support, u.s. gov't, p.h.s.; support, u.s. gov't, non-p.h.s.; zygomycetes |
| Journal Title: | Clinical Infectious Diseases |
| Volume: | 15 |
| Issue: | Suppl. 1 |
| ISSN: | 1058-4838 |
| Publisher: | Oxford University Press |
| Date Published: | 1992-11-01 |
| Start Page: | S206 |
| End Page: | S215 |
| Language: | English |
| DOI: | 10.1093/clind/15.Supplement_1.S206 |
| PUBMED: | 1477232 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 30 July 2019 -- Source: Scopus |
